Lei, Yang
Dr. Yang Lei joined CICS in August 2014 after he completed his PhD in 2014 with major in Bioengineering at Clemson University in the lab of Professor Naren Vyavahare. The title of his thesis was “MECHANISMS AND REVERSAL OF ELASTIN SPECIFIC MEDIAL ARTERIAL CALCIFICATION” from which he published several peer reviewed publications. Dr.Lei got PhD scholarship award from China Scholarship Council during 2010-2014. Prior to his PhD work, Dr. Lei did his M.S. at Beijing University of Aeronautics and Astronautics and B.S. in Beijing University of Aeronautics and Astronautics with major in Materials Science and Engineering.
Dr. Lei is continuing to do translational research at CICS in Dr. Elena Aikawa’s group. Specifically Dr. Lei is looking to identify novel targets regulating peripheral blood mononuclear cell (PBMC) derived osteoclast differentiation to reverse cardiovascular calcification.
Publications
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Nagy E, Lei Y, Martínez-Martínez E, Body SC, Schlotter F, Creager M, Assmann A, Khabbaz K, Libby P, Hansson GK, Aikawa E
Interferon-γ Released by Activated CD8(+) T Lymphocytes Impairs the Calcium Resorption Potential of Osteoclasts in Calcified Human Aortic Valves.
Lei Y, Iwashita M, Choi J, Aikawa M, Aikawa E
N-acetylglucosamine-1-Phosphate Transferase Suppresses Lysosomal Hydrolases in Dysfunctional Osteoclasts: A Potential Mechanism for Vascular Calcification
Lei Y, Nosoudi N, Vyavahare N
Targeted chelation therapy with EDTA-loaded albumin nanoparticles regresses arterial calcification without causing systemic side effects.
Sinha A, Shaporev A, Nosoudi N, Lei Y, Vertegel A, Lessner S, Vyavahare N
Nanoparticle targeting to diseased vasculature for imaging and therapy.
Lei Y, Sinha A, Nosoudi N, Grover A, Vyavahare N
Hydroxyapatite and calcified elastin induce osteoblast-like differentiation in rat aortic smooth muscle cells.
Lei Y, Grover A, Sinha A, Vyavahare N
Efficacy of reversal of aortic calcification by chelating agents.