Our History and Mission
The Center for Interdisciplinary Cardiovascular Sciences (CICS) was established in 2009 by a collaboration agreement between the Brigham and Women’s Hospital (Boston, MA) and Kowa Company, Ltd. (Tokyo, Japan).
The goals of CICS are to promote better understanding of the mechanisms of cardiovascular inflammation and cardiometabolic disorders and to enhance further advancement in cardiovascular prevention and therapy through a translational research program that consists of investigators from academia and industry with multidisciplinary backgrounds acting in concert in a shared space.
Max joined CICS in 2012 and is a Research Scientist in Elena Aikawa’s Group, where he works on novel therapeutic targets and mechanistic biology for extracellular vesicles, mitochondrial dynamics, cardiovascular calcification, inflammation, lipid metabolism, and cardiometabolic diseases. He obtained his PhD in Biochemistry from Dartmouth in the Molecular and Cell Biology program where he studied lipid metabolism in neurodegenerative diseases and atherosclerosis in the lab of T.Y. Chang. He is an author on over two dozen papers including a 2020 CICS publication in Arterioscler Thromb Vasc Biol. that demonstrates selective retinoid modulator effects in human cardiovascular calcification and APOCIII secretion. Max also published a 2019 Frontiers paper with a former CICS scientist, Shinji Goto, in which CICS’s XINA clustering software was used to analyze proteomics datasets to help standardize calcific aortic valve disease research. With Elena Aikawa, Max published a 2019 paper in Nature Reviews Cardiology on artificial intelligence and big data in calcification mechanistic discovery, a research area CICS is actively pursuing. Science is Max’s biggest hobby, but he also enjoys photography, occasional travel, corgis, and politics having volunteered with a 2020 presidential campaign and served as a delegate to the Massachusetts Democratic Party convention.
Takayuki Asahara, MD, PhD
Edward A. Fisher, MD, PhD, MPH
Thomas M. Michel, MD, PhD
Heart Valve Translational Research Program Center