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Jung B, Yagi H, Kuo A, Dorweiler TF, Aikawa M, Kasai T, Singh SA, Dannenberg AJ, Fu Z, Niaudet C, Smith LEH, Hla T
ApoM-bound S1P acts via endothelial S1PR1 to suppress choroidal neovascularization and vascular leakage.
Angiogenesis. 2025;28(2):24 - PMID: 40266369 - PMCID: PMC12018641 - DOI: 10.1007/s10456-025-09975-7
Goody PR, Christmann D, Goody D, Hildebrand S, Billig H, Nehl D, Chennupati R, Gladka M, Wilhelm-Jüngling K, Uchida S, Iris-Bibli S, Moore JB, Hamdani N, Paneni F, Pullamsetti SS, Zimmer S, Jansen F, Bakhtiary F, Aikawa E, Pfeifer A, Nickenig G, Hosen MR
Calcific aortic valve disease augments vesicular microRNA-145-5p to regulate the calcification of valvular interstitial cells via cellular crosstalk.
Basic Res Cardiol. 2025;:ePub - PMID: 40847220 - DOI: 10.1007/s00395-025-01133-w
Clift CL, Blaser MC, Bartoli-Leonard F, Schlotter F, Higashi H, Kuraoka S, Kasai T, Turner ME, Pham T, Perez KA, Robson SC, Body SC, Muehlschlegel JD, Aikawa M, Singh SA, Aikawa E
Sexual Dimorphism of Plasma and Tissue Proteomes in Human Calcific Aortic Valve Stenosis Pathogenesis.
Arterioscler Thromb Vasc Biol. 2025;:ePub - PMID: 40808650 - DOI: 10.1161/ATVBAHA.125.322560
Sun J, Aikawa M, Ashktorab H, Beckmann ND, Enger ML, Espinosa JM, Gai X, Horne BD, Keim P, Lasky-Su J, Letts R, Maier CL, Mandal M, Nichols L, Roan NR, Russell MW, Rutter J, Saade GR, Sharma K, Shiau S, Thibodeau SN, Yang S, Miele L, NIH Researching COVID to Enhance Recovery (RECOVER) Consortium
A multi-omics strategy to understand PASC through the RECOVER cohorts: a paradigm for a systems biology approach to the study of chronic conditions.
Front Syst Biol. 2025;4:1422384 - PMID: 40809128 - PMCID: PMC12342036 - DOI: 10.3389/fsysb.2024.1422384
Jha PK, Aikawa M, Aikawa E
Indoxyl sulfate: fuelling cardiovascular inflammation and calcification.
Cardiovasc Res. 2025;:ePub - PMID: 40795292 - DOI: 10.1093/cvr/cvaf134
Clift CL, Goudot G, Bogut G, Kasai T, van Kampen A, Negrao Pantaleao A, Messas E, Aikawa M, Singh SA, Levine RA, Pernot M, Aikawa E
Short- and Long-Term Effects of Pulsed Ultrasound Cavitation Therapy of Calcified Valvular Interstitial Cells in Culture.
Ultrasound Med Biol. 2025;:ePub - PMID: 40796501 - DOI: 10.1016/j.ultrasmedbio.2025.06.026
Chelvanambi S, Chen H, De Vries MR, Fang Y, Fredman G, Gomez D, Iwata H, Uchida S, Yanagisawa H, Aikawa M
Editorial: New trends in vascular biology 2024.
Front Cardiovasc Med. 2025;12:1649558 - PMID: 40777568 - PMCID: PMC12328353 - DOI: 10.3389/fcvm.2025.1649558
Delwarde C, Matamalas JT, Chelvanambi S, Kasai T, Shlayen G, Santinelli-Pestana DV, Zamani M, Aikawa E, Aikawa M, Singh SA
Nanoparticle-enabled plasma proteomics of a mouse atherosclerosis model.
bioRxiv. 2025;:ePub - PMID: 40766711 - PMCID: PMC12324543 - DOI: 10.1101/2025.08.01.667173
Boeck M, Yagi H, Lundgren P, Pivodic A, Nilsson AK, Zeng Y, Chen CT, Kasai T, Lee D, Nian S, Hirst V, Neilsen K, Wang C, Lee J, Yu M, McCutcheon A, Singh SA, Aikawa M, Bazinet RP, Fu Z, Hellström A, Smith LE
Combined dietary omega-3 and omega-6 fatty acids protect against hyperglycemia-associated retinopathy in neonatal mice.
Pharmacol Res. 2025;219:107877 - PMID: 40706777 - DOI: 10.1016/j.phrs.2025.107877
Cahalane RME, Meuris B, Matamalas JT, Blaser MC, Billaud M, Kasai T, Hendrickx A, Goeminne LJE, Muehlschlegel J, Rega F, Aikawa M, McNamara L, Singh SA, Clift CL, Aikawa E
Cross-species proteomics quantification pipeline distinguishes donor versus host extracellular matrix in explanted biomaterials.
bioRxiv. 2025;:ePub - PMID: 40667106 - PMCID: PMC12262681 - DOI: 10.1101/2025.06.24.661315
Weiss L, Aikawa E
Glycolysis hijacked: a novel pathogenic role of lipoprotein(a) in valve disease.
Eur Heart J Open. 2025;5(4):oeaf069 - PMID: 40654528 - PMCID: PMC12246370 - DOI: 10.1093/ehjopen/oeaf069
Lupieri A, Becker-Greene D, Le TD, Roschel MM, Jha PK, Sonawane AR, Mullick A, Tsimikas S, Kuraoka S, Singh SA, Aikawa M, Aikawa E
Antisense Oligonucleotide Targeting Sortilin Reduces Vascular Calcification in Mice in a Sex-Dependent Manner.
Arterioscler Thromb Vasc Biol. 2025;45(8):1398-1415 - PMID: 40501380 - DOI: 10.1161/ATVBAHA.124.321999
Higuita ML, Ajenu EO, Bolger-Chen M, Olverson G, Akbari Ghavimi SA, Lee SY, Kasai T, Michaud W, Chijioke C, Ruidas B, Pitti A, Minie N, Catricala J, Vincent D, Li S, D'Alessandro D, Aikawa E, Singh SA, Billaud M, Osho AA, Tessier SN, Rabi SA
Alternative preservation strategies of DCD hearts: Effect of cold ischemia time before normothermic machine perfusion.
medRxiv. 2025;:ePub - PMID: 40502597 - PMCID: PMC12154999 - DOI: 10.1101/2025.06.04.25329001
Raju S, Turner ME, Cao C, Abdul-Samad M, Punwasi N, Blaser MC, Cahalane RME, Botts SR, Prajapati K, Patel S, Wu R, Gustafson D, Galant NJ, Fiddes L, Chemaly M, Hedin U, Matic L, Seidman MA, Subasri V, Singh SA, Aikawa E, Fish JE, Howe KL
Multiomic Landscape of Extracellular Vesicles in Human Carotid Atherosclerotic Plaque Reveals Endothelial Communication Networks.
Arterioscler Thromb Vasc Biol. 2025;45(7):1277-1305 - PMID: 40438929 - PMCID: PMC12188822 - DOI: 10.1161/ATVBAHA.124.322324
Lupieri A, Aikawa E
Decoding calcific aortic valve disease: is liver X receptor the key to lipid metabolism?
Cardiovasc Res. 2025;121(6):844-846 - PMID: 40389228 - DOI: 10.1093/cvr/cvaf080
Yagi H, Qiu C, Zeng Y, Boeck M, Nian S, Chen CT, Harman JC, Kasai T, Lee J, Hirst V, Neilsen K, Wang C, Bora K, Maurya M, Rodrick T, Grumbine M, Yang Y, Hua Z, Sweet IR, Singh SA, Aikawa M, Chen J, Fu Z
Serine supplementation suppresses hypoxia-induced pathological retinal angiogenesis.
Theranostics. 2025;15(11):5087-5105 - PMID: 40303351 - PMCID: PMC12036884 - DOI: 10.7150/thno.105299
Kasai T, Nakamura Y, Aikawa M, Singh SA
In-Source Collision-Induced Dissociation (CID) Improves Higher-Energy Collisional Dissociation (HCD)-Dependent Fragmentation of ADP-Ribosyl Peptides.
Rapid Commun Mass Spectrom. 2025;39(4):e9961 - PMID: 39632390 - PMCID: PMC11617611 - DOI: 10.1002/rcm.9961
Bortolin RH, de Souza Leite F, Luchessi AD, Esposito J, Barbosa IN, Costa de Freitas RC, Sonawane AR, Singh SA, Aikawa E, Silva KAT, Hirata TDC, Neta APR, Goulart E, Caires-Júnior LC, Mata Martins TMD, Semedo P, de Paula Moreira D, Naslavsky M, Faludi AA, Gonçalves RM, Araujo DB, Malaquias VB, Ferreira GM, DeOcesano-Pereira C, Chudzinski-Tavassi AM, Pu WT, Zatz M, Hirata RDC, Hirata MH
Translational insights into statin-induced myotoxicity: differential impact of lipophilic and hydrophilic statins on iPSC-derived skeletal muscle cells from patients with familial hypercholesterolemia.
Toxicology. 2025;515:154159 - PMID: 40254247 - DOI: 10.1016/j.tox.2025.154159
Jha PK, Nakano T, Itto LYU, Barbeiro MC, Lupieri A, Aikawa E, Aikawa M
Vascular inflammation in chronic kidney disease: the role of uremic toxins in macrophage activation.
Front Cardiovasc Med. 2025;12:1574489 - PMID: 40201789 - PMCID: PMC11975941 - DOI: 10.3389/fcvm.2025.1574489
Lupieri A, Jha PK, Nizet V, Dutra WO, Nunes MCP, Levine RA, Aikawa E
Rheumatic heart valve disease: navigating the challenges of an overlooked autoimmune disorder.
Front Cardiovasc Med. 2025;12:1537104 - PMID: 40182432 - PMCID: PMC11966398 - DOI: 10.3389/fcvm.2025.1537104
Song N, Ji E, Yu JE, Choi KH, Kim DH, Song JM, Kang DH, Song JK, Yu J, Kim K, Lee S, Aikawa E
Spermidine Enhances Mitochondrial Function and Mitigates Aortic Valve Calcification: Implications for DNA Methyltransferase-1 Activity.
JACC Basic Transl Sci. 2025;10(3):345-366 - PMID: 40139876 - PMCID: PMC12013848 - DOI: 10.1016/j.jacbts.2024.11.011
Lansac E, Veen KM, Joseph A, Jaber PB, Sossi F, Das-Gupta Z, Aktaa S, Sádaba JR, Thourani VH, Dahle G, Szeto WY, Bakaeen F, Aikawa E, Schoen FJ, Girdauskas E, Almeida A, Zuckermann A, Meuris B, Stott J, Kluin J, Meel R, Woan W, Colgan D, Jneid H, Balkhy H, Szerlip M, Preventza O, Shah P, Rigolin VH, Medica S, Holmes P, Sitges M, Pibarot P, Donal E, Hahn RT, Takkenberg JJM
The First International Consortium for Health Outcomes Measurement (ICHOM) Standard Dataset for Reporting Outcomes in Heart Valve Disease: Moving From Device- to Patient-Centered Outcomes: Developed by a multisociety taskforce coordinated by the Heart Valve Society (HVS) including the American Heart Association (AHA), the American College of Cardiology (ACC), the European Association for Cardio-Thoracic Surgery (EACTS), the European Society of Cardiology (ESC), The Society of Thoracic Surgeons (STS), the Australian & New Zealand Society of Cardiac & Thoracic Surgeons (ANZSCTS), the International Society for Applied Cardiovascular Biology (ISACB), the International Society for Minimally Invasive Cardiothoracic Surgery (ISMICS), the South African Heart Association (SHA), Heart Valve Voice, and Global Heart Hub.
Ann Thorac Surg Short Rep. 2025;3(1):71-85 - PMID: 40098847 - PMCID: PMC11910787 - DOI: 10.1016/j.atssr.2024.05.005
Boeck M, Yagi H, Chen CT, Zeng Y, Lee D, Nian S, Kasai T, Lee J, Hirst V, Wang C, Neilsen K, Rodrick TC, McCutcheon A, Yu M, Lodhi IJ, Singh SA, Aikawa M, Bazinet RP, Fu Z
Nutrient supplementation mitigates retinal dysfunction in Acox1 knockout mice with impaired peroxisomal fatty acid oxidation.
J Adv Res. 2025;:ePub - PMID: 40049514 - DOI: 10.1016/j.jare.2025.03.004
Lansac E, Veen KM, Joseph A, Blancarte Jaber P, Sossi F, Das-Gupta Z, Aktaa S, Sádaba JR, Thourani VH, Dahle G, Szeto WY, Bakaeen F, Aikawa E, Schoen FJ, Girdauskas E, Almeida A, Zuckermann A, Meuris B, Stott J, Kluin J, Meel R, Woan W, Colgan D, Jneid H, Balkhy H, Szerlip M, Preventza O, Shah P, Rigolin VH, Medica S, Holmes P, Sitges M, Pibarot P, Donal E, Hahn RT, Takkenberg JJM
The First International Consortium for Health Outcomes Measurement (ICHOM) Standard Dataset for Reporting Outcomes in Heart Valve Disease: Moving From Device- to Patient-Centered Outcomes.
Innovations (Phila). 2025;20(2):133-147 - PMID: 39968696 - PMCID: PMC12089684 - DOI: 10.1177/15569845241269309
Lansac E, Veen KM, Joseph A, Blancarte Jaber P, Sossi F, Das-Gupta Z, Aktaa S, Sádaba JR, Thourani VH, Dahle G, Szeto WY, Bakaeen F, Aikawa E, Schoen FJ, Girdauskas E, Almeida A, Zuckermann A, Meuris B, Stott J, Kluin J, Meel R, Woan W, Colgan D, Jneid H, Balkhy H, Szerlip M, Preventza O, Shah P, Rigolin VH, Medica S, Holmes P, Sitges M, Pibarot P, Donal E, Hahn RT, Takkenberg JJM
The First International Consortium for Health Outcomes Measurement (ICHOM) Standard Dataset for Reporting Outcomes in Heart Valve Disease: Moving From Device- to Patient-Centered Outcomes: Developed by a multisociety taskforce coordinated by the Heart Valve Society (HVS) including the American Heart Association (AHA), the American College of Cardiology (ACC), the European Association for Cardio-Thoracic Surgery (EACTS), the European Society of Cardiology (ESC), The Society of Thoracic Surgeons (STS), the Australian & New Zealand Society of Cardiac & Thoracic Surgeons (ANZSCTS), the International Society for Applied Cardiovascular Biology (ISACB), the International Society for Minimally Invasive Cardiothoracic Surgery (ISMICS), the South African Heart Association (SHA), Heart Valve Voice, and Global Heart Hub.
JACC Adv. 2025;4(4):101059 - PMID: 39966045 - PMCID: PMC12139239 - DOI: 10.1016/j.jacadv.2024.101059
Lansac E, Veen KM, Joseph A, Blancarte Jaber P, Sossi F, Das-Gupta Z, Aktaa S, Sádaba JR, Thourani VH, Dahle G, Szeto WY, Bakaeen F, Aikawa E, Schoen FJ, Girdauskas E, Almeida A, Zuckermann A, Meuris B, Stott J, Kluin J, Meel R, Woan W, Colgan D, Jneid H, Balkhy H, Szerlip M, Preventza O, Shah P, Rigolin VH, Medica S, Holmes P, Sitges M, Pibarot P, Donal E, Hahn RT, Takkenberg JJM
The First International Consortium for Health Outcomes Measurement (ICHOM) Standard Dataset for Reporting Outcomes in Heart Valve Disease: Moving From Device- to Patient-Centered Outcomes.
Circ Cardiovasc Qual Outcomes. 2025;18(3):e000128 - PMID: 39957624 - PMCID: PMC11917533 - DOI: 10.1161/HCQ.0000000000000128
Lansac E, Veen KM, Joseph A, Jaber PB, Sossi F, Das-Gupta Z, Aktaa S, Sádaba JR, Thourani VH, Dahle G, Szeto WY, Bakaeen F, Aikawa E, Schoen FJ, Girdauskas E, Almeida A, Zuckermann A, Meuris B, Stott J, Kluin J, Meel R, Woan W, Colgan D, Jneid H, Balkhy H, Szerlip M, Preventza O, Shah P, Rigolin VH, Medica S, Holmes P, Sitges M, Pibarot P, Donal E, Hahn RT, Takkenberg JJM
The first International Consortium for Health Outcomes Measurement (ICHOM) standard dataset for reporting outcomes in heart valve disease: moving from device- to patient- centered outcomes.
Eur Heart J Qual Care Clin Outcomes. 2025;11(5):515-528 - PMID: 39957667 - PMCID: PMC12342911 - DOI: 10.1093/ehjqcco/qcae051
Lansac E, Veen KM, Joseph A, Jaber PB, Sossi F, Das-Gupta Z, Aktaa S, Rafael Sádaba J, Thourani VH, Dahle G, Szeto WY, Bakaeen F, Aikawa E, Schoen FJ, Girdauskas E, Almeida A, Zuckermann A, Meuris B, Stott J, Kluin J, Meel R, Woan W, Colgan D, Jneid H, Balkhy H, Szerlip M, Preventza O, Shah P, Rigolin VH, Medica S, Holmes P, Sitges M, Pibarot P, Donal E, Hahn RT, Takkenberg JJM
The First International Consortium for Health Outcomes Measurement (ICHOM) Standard Dataset for Reporting Outcomes in Heart Valve Disease: Moving From Device- to Patient-Centered Outcomes.
Eur J Cardiothorac Surg. 2025;67(2):ePub - PMID: 39957685 - PMCID: PMC11842054 - DOI: 10.1093/ejcts/ezae254
Boucher DM, Robichaud S, Lorant V, Leon JS, Suliman I, Rasheed A, Susser LI, Emerton C, Geoffrion M, De Jong E, Bowdish DME, Aikawa M, Aikawa E, Singh SA, Rayner KJ, Ouimet M
Age-Related Impairments in Immune Cell Efferocytosis and Autophagy Hinder Atherosclerosis Regression.
Arterioscler Thromb Vasc Biol. 2025;45(4):481-495 - PMID: 39945065 - PMCID: PMC11936474 - DOI: 10.1161/ATVBAHA.124.321662
Bhattacharjee S, Gao J, Lu YW, Eisa-Beygi S, Wu H, Li K, Birsner AE, Wong S, Song Y, Shyy JY, Cowan DB, Huang W, Wei W, Aikawa M, Shi J, Chen H
Endothelial FOXM1 and Dab2 promote diabetic wound healing.
JCI Insight. 2025;10(2):ePub - PMID: 39846251 - PMCID: PMC11790024 - DOI: 10.1172/jci.insight.186504
Halu A, Chelvanambi S, Decano JL, Matamalas JT, Whelan M, Asano T, Kalicharran N, Singh SA, Loscalzo J, Aikawa M
Integrating pharmacogenomics and cheminformatics with diverse disease phenotypes for cell type-guided drug discovery.
Genome Med. 2025;17(1):7 - PMID: 39833831 - PMCID: PMC11744892 - DOI: 10.1186/s13073-025-01431-x
Costa de Freitas RC, Bortolin RH, Kuraoka S, Rogers MA, Blaser MC, Chelvanambi S, Borges JB, de Oliveira VF, Dagli-Hernandez C, Bastos GM, da Silva Rodrigues Marçal E, Malaquias VB, Gonçalves RM, Faludi AA, Silbiger VN, Luchessi AD, Aikawa M, Crespo Hirata RD, Singh SA, Aikawa E, Hirata MH
Integrative analysis of miRNAs and proteins in plasma extracellular vesicles of patients with familial hypercholesterolemia.
Clin Chim Acta. 2025;568:120123 - PMID: 39778611 - DOI: 10.1016/j.cca.2025.120123
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