Center for Interdisciplinary Cardiovascular Sciences

Jha PK, Vijay A, Halu A, Uchida S, Aikawa M

Gene Expression Profiling Reveals the Shared and Distinct Transcriptional Signatures in Human Lung Epithelial Cells Infected With SARS-CoV-2, MERS-CoV, or SARS-CoV: Potential Implications in Cardiovascular Complications of COVID-19.

Front Cardiovasc Med. 2021;7:623012 - PMID: 33521069 - PMCID: PMC7844200 - DOI: 10.3389/fcvm.2020.623012

Sutton NR, Malhotra R, Hilaire CS, Aikawa E, Blumenthal RS, Gackenbach G, Goyal P, Johnson A, Nigwekar SU, Shanahan CM, Towler DA, Wolford BN, Chen Y

Molecular Mechanisms of Vascular Health: Insights From Vascular Aging and Calcification.

Arterioscler Thromb Vasc Biol. 2022;43(1):15-29 - PMID: 36412195 - PMCID: PMC9793888 - DOI: 10.1161/ATVBAHA.122.317332

Krohn JB, Aikawa E, Aikawa M, Hutcheson JD, Sahoo S, Fish JE

Editorial: Extracellular vesicles in cardiovascular inflammation and calcification.

Front Cardiovasc Med. 2022;9:1077124 - PMID: 36426218 - PMCID: PMC9680153 - DOI: 10.3389/fcvm.2022.1077124

Corti A, De Paolis A, Grossman P, Dinh PA, Aikawa E, Weinbaum S, Cardoso L

The effect of plaque morphology, material composition and microcalcifications on the risk of cap rupture: A structural analysis of vulnerable atherosclerotic plaques.

Front Cardiovasc Med. 2022;9:1019917 - PMID: 36277774 - PMCID: PMC9583261 - DOI: 10.3389/fcvm.2022.1019917

Kuo A, Checa A, Niaudet C, Jung B, Fu Z, Wheelock CE, Singh SA, Aikawa M, Smith LEH, Proia RL, Hla T

Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasi.

Elife. 2022;11:ePub - PMID: 36197001 - PMCID: PMC9578713 - DOI: 10.7554/eLife.78861

Morgan S, Lee LH, Halu A, Nicolau JS, Higashi H, Ha AH, Wen JR, Daugherty A, Libby P, Cameron SJ, Mix D, Aikawa E, Owens AP, Singh SA, Aikawa M

Identifying novel mechanisms of abdominal aortic aneurysm via unbiased proteomics and systems biology.

Front Cardiovasc Med. 2022;9:889994 - PMID: 35990960 - PMCID: PMC9382335 - DOI: 10.3389/fcvm.2022.889994

Atkins SK, Sonawane AR, Brouwhuis R, Barrientos J, Ha A, Rogers M, Tanaka T, Okui T, Kuraoka S, Singh SA, Aikawa M, Aikawa E

Induced pluripotent stem cell-derived smooth muscle cells to study cardiovascular calcification.

Front Cardiovasc Med. 2022;9:925777 - PMID: 35958427 - PMCID: PMC9357895 - DOI: 10.3389/fcvm.2022.925777

Uchida S, Yu J, Goldman M, Asmis R, Yang X, Aikawa E, Bourantas C, Aikawa M, Tevaearai Stahel H

Editorial: Research reproducibility and preventing fraud.

Front Cardiovasc Med. 2022;9:979467 - PMID: 35979020 - PMCID: PMC9376614 - DOI: 10.3389/fcvm.2022.979467

Marsit O, Clavel MA, Paquin A, Deschênes V, Hadjadj S, Sénéchal-Dumais I, Couet J, Arsenault M, Handschumacher MD, Levine RA, Aikawa E, Pibarot P, Beaudoin J

Effects of Cyproheptadine on Mitral Valve Remodeling and Regurgitation After Myocardial Infarction.

J Am Coll Cardiol. 2022;80(5):500-510 - PMID: 35902173 - DOI: 10.1016/j.jacc.2022.05.025

Wang L, Xu GE, Pan L, Aikawa E, Aikawa M, Xiao J, Huang NF

Editorial: Frontiers in Cardiovascular Medicine: Rising Stars 2021.

Front Cardiovasc Med. 2022;9:928981 - PMID: 35757336 - PMCID: PMC9218798 - DOI: 10.3389/fcvm.2022.928981

Asano T, Chelvanambi S, Decano JL, Whelan MC, Aikawa E, Aikawa M

In silico Drug Screening Approach Using L1000-Based Connectivity Map and Its Application to COVID-19.

Front Cardiovasc Med. 2022;9:842641 - PMID: 35402570 - PMCID: PMC8989014 - DOI: 10.3389/fcvm.2022.842641

Decano JL, Iwamoto Y, Goto S, Lee JY, Matamalas JT, Halu A, Blaser M, Lee LH, Pieper B, Chelvanambi S, Silva-Nicolau J, Bartoli-Leonard F, Higashi H, Shibata H, Vyas P, Wang J, Gostjeva E, Body SC, Singh SA, Aikawa M, Aikawa E

A disease-driver population within interstitial cells of human calcific aortic valves identified via single-cell and proteomic profiling.

Cell Rep. 2022;39(2):110685 - PMID: 35417712 - DOI: 10.1016/j.celrep.2022.110685

Paquin A, Marsit O, Deschênes V, Rouabhia D, Hadjadj S, Clisson M, Robitaille C, Aikawa E, Levine RA, Pibarot P, Clavel MA, Beaudoin J

Progression of aortic stenosis after an acute myocardial infarction.

Open Heart. 2022;9(1):ePub - PMID: 35728891 - PMCID: PMC9214429 - DOI: 10.1136/openhrt-2022-002046

Bartoli-Leonard F, Turner ME, Zimmer J, Chapurlat R, Pham T, Aikawa M, Pradhan AD, Szulc P, Aikawa E

Elevated lipoprotein(a) as a predictor for coronary events in older men.

J Lipid Res. 2022;63(8):100242 - PMID: 35724702 - PMCID: PMC9304778 - DOI: 10.1016/j.jlr.2022.100242

Sonawane AR, Aikawa E, Aikawa M

Connections for Matters of the Heart: Network Medicine in Cardiovascular Diseases.

Front Cardiovasc Med. 2022;9:873582 - PMID: 35665246 - PMCID: PMC9160390 - DOI: 10.3389/fcvm.2022.873582

Dacano JL, Aikawa M, Singh SA

Promise of a Novel Bedside-to-Bench Paradigm: Can Percutaneous Coronary Intervention Proteomics Balloon Into Clinical Practice?

Arterioscler Thromb Vasc Biol. 2022;42(7):865-867 - PMID: 35616034 - DOI: 10.1161/ATVBAHA.122.317802

Garelnabi M, Cowdin M, Fang Y, Shrestha B, Ushio-Fukai M, Aikawa E, Graham G, Molema G, Yanagisawa H, Aikawa M

Embracing Diversity, Equity, and Inclusion in the Scientific Community-Viewpoints of the Diversity, Equity, and Inclusion Committee of the North American Vascular Biology Organization.

Front Cardiovasc Med. 2022;9:863256 - PMID: 35463765 - PMCID: PMC9021758 - DOI: 10.3389/fcvm.2022.863256

Aikawa E, Hutcheson JD

The Developmental Origin of Calcific Aortic Stenosis.

N Engl J Med. 2022;386(14):1372-1374 - PMID: 35388675 - DOI: 10.1056/NEJMcibr2200439

Gomes NFA, Silva VR, Levine RA, Esteves WAM, de Castro ML, Passos LSA, Dal-Bianco JP, Pantaleão AN, da Silva JLP, Tan TC, Dutra WO, Aikawa E, Hung J, Nunes MCP

Progression of Mitral Regurgitation in Rheumatic Valve Disease: Role of Left Atrial Remodeling.

Front Cardiovasc Med. 2022;9:862382 - PMID: 35360029 - PMCID: PMC8962951 - DOI: 10.3389/fcvm.2022.862382

Alvandi Z, Nagata Y, Passos LSA, Hashemi Gheinani A, Guerrero JL, Wylie-Sears J, Romero DC, Morris BA, Sullivan SM, Yaghoubian KM, Alvandi A, Adam RM, Aikawa E, Levine RA, Bischoff J

Wnt Site Signaling Inhibitor Secreted Frizzled-Related Protein 3 Protects Mitral Valve Endothelium From Myocardial Infarction-Induced Endothelial-to-Mesenchymal Transition.

J Am Heart Assoc. 2022;11(7):e023695 - PMID: 35348006 - PMCID: PMC9075477 - DOI: 10.1161/JAHA.121.023695

Davidson SM, Boulanger CM, Aikawa E, Badimon L, Barile L, Binder CJ, Brisson A, Buzas E, Emanueli C, Jansen F, Katsur M, Lacroix R, Lim SK, Mackman N, Mayr M, Menasché P, Nieuwland R, Sahoo S, Takov K, Thum T, Vader P, Wauben MHM, Witwer K, Sluijter JPG

Methods for the identification and characterization of extracellular vesicles in cardiovascular studies - from exosomes to microvesicles.

Cardiovasc Res. 2022;119(1):45-63 - PMID: 35325061 - PMCID: PMC10233250 - DOI: 10.1093/cvr/cvac031

Passos LSA, Jha PK, Becker-Greene D, Blaser MC, Romero D, Lupieri A, Sukhova GK, Libby P, Singh SA, Dutra WO, Aikawa M, Levine RA, Nunes MCP, Aikawa E

Prothymosin Alpha: A Novel Contributor to Estradiol Receptor Alpha-Mediated CD8⁺ T-Cell Pathogenic Responses and Recognition of Type 1 Collagen in Rheumatic Heart Valve Disease.

Circulation. 2022;145(7):531-548 - PMID: 35157519 - PMCID: PMC8869797 - DOI: 10.1161/CIRCULATIONAHA.121.057301

Rogers MA, Atkins SK, Zheng KH, Singh SA, Chelvanambi S, Pham TH, Kuraoka S, Stroes ESG, Aikawa M, Aikawa E

Lipoprotein(a) Induces Vesicular Cardiovascular Calcification Revealed With Single-Extracellular Vesicle Analysis.

Front Cardiovasc Med. 2022;9:778919 - PMID: 35155626 - PMCID: PMC8831739 - DOI: 10.3389/fcvm.2022.778919

Sawada H, Katsumata Y, Higashi H, Zhang C, Li Y, Morgan S, Lee LH, Singh SA, Chen JZ, Franklin MK, Moorleghen JJ, Howatt DA, Rateri DL, Shen YH, LeMaire SA, Aikawa M, Majesky MW, Lu HS, Daugherty A

Second Heart Field-derived Cells Contribute to Angiotensin II-mediated Ascending Aortopathies.

Circulation. 2022;145(13):987-1001 - PMID: 35143327 - PMCID: PMC9008740 - DOI: 10.1161/CIRCULATIONAHA.121.058173

Buffolo F, Monticone S, Camussi G, Aikawa E

Role of Extracellular Vesicles in the Pathogenesis of Vascular Damage.

Hypertension. 2022;79(5):863-873 - PMID: 35144490 - PMCID: PMC9010370 - DOI: 10.1161/HYPERTENSIONAHA.121.17957

Tanaka T, Asano T, Okui T, Kuraoka S, Singh SA, Aikawa M, Aikawa E

Computational Screening Strategy for Drug Repurposing Identified Niclosamide as Inhibitor of Vascular Calcification.

Front Cardiovasc Med. 2022;8:826529 - PMID: 35127876 - PMCID: PMC8811128 - DOI: 10.3389/fcvm.2021.826529

Human P, Bezuidenhout D, Aikawa E, Zilla P

Residual Bioprosthetic Valve Immunogenicity: Forgotten, Not Lost.

Front Cardiovasc Med. 2022;8:760635 - PMID: 35059444 - PMCID: PMC8764456 - DOI: 10.3389/fcvm.2021.760635

Kraler S, Blaser MC, Aikawa E, Camici GG, Luscher TF

Calcific aortic valve disease: from molecular and cellular mechanisms to medical therapy.

Eur Heart J. 2021;43(7):683-697 - PMID: 34849696 - PMCID: PMC8843796 - DOI: 10.1093/eurheartj/ehab757

van der Ven CFT, Tibbitt MW, Conde J, van Mil A, Hjortnaes J, Doevendans PA, Sluijter JPG, Aikawa E, Langer RS

Controlled delivery of gold nanoparticle-coupled miRNA therapeutics via an injectable self-healing hydrogel.

Nanoscale. 2021;13(48):20451-20461 - PMID: 34817483 - PMCID: PMC8675028 - DOI: 10.1039/d1nr04973a

Iwata H, Osborn EA, Ughi GJ, Murakami K, Goettsch C, Hutcheson JD, Mauskapf A, Mattson PC, Libby P, Singh SA, Matamalas J, Aikawa E, Tearney GJ, Aikawa M, Jaffer FA

Highly Selective PPARα (Peroxisome Proliferator-Activated Receptor α) Agonist Pemafibrate Inhibits Stent Inflammation and Restenosis Assessed by Multimodality Molecular-Microstructural Imaging.

J Am Heart Assoc. 2021;10(20):e020834 - PMID: 34632804 - PMCID: PMC8751880 - DOI: 10.1161/JAHA.121.020834

Kuraoka S, Higashi H, Yanagihara Y, Sonawane AR, Mukai S, Mlynarchik AK, Whelan MC, Hottiger MO, Nasir W, Delanghe B, Aikawa M, Singh SA

A Novel Spectral Annotation Strategy Streamlines Reporting of mono-ADP-ribosylated Peptides Derived from Mouse Liver and Spleen in Response to IFN-γ.

Mol Cell Proteomics. 2021;21(4):100153 - PMID: 34592425 - PMCID: PMC9014395 - DOI: 10.1016/j.mcpro.2021.100153

Zhang H, Chen ZB, Fredman G, Gomez D, Grumbach IM, Huang NF, Nguyen P, Ouimet M, Sutton NR, Aikawa E

What Makes a Great Mentor: Interviews With Recipients of the ATVB Mentor of Women Award.

Arterioscler Thromb Vasc Biol. 2021;41(11):2641-2647 - PMID: 34547925 - PMCID: PMC8551033 - DOI: 10.1161/ATVBAHA.121.316558

Meerman M, Driessen R, van Engeland NCA, Bergsma I, Steenhuijsen JLG, Kozono D, Aikawa E, Hjortnaes J, Bouten CVC

Radiation Induces Valvular Interstitial Cell Calcific Response in an in vitro Model of Calcific Aortic Valve Disease.

Front Cardiovasc Med. 2021;8:687885 - PMID: 34527708 - PMCID: PMC8435633 - DOI: 10.3389/fcvm.2021.687885

Bartoli-Leonard F, Zimmer J, Aikawa E

Innate and adaptative immunity: The understudied driving force of heart valve disease.

Cardiovasc Res. 2021;117(13):2506-2524 - PMID: 34432007 - PMCID: PMC8783388 - DOI: 10.1093/cvr/cvab273

Lupieri A, Nagata Y, Passos LSA, Beker-Greene D, Kirkwood KA, Wylie-Sears J, Alvandi Z, Higashi H, Hung JW, Singh SA, Bischoff J, Levine RA, Aikawa E

Integration of Functional Imaging, Cytometry, and Unbiased Proteomics Reveals New Features of Endothelial-to-Mesenchymal Transition in Ischemic Mitral Valve Regurgitation in Human Patients.

Front Cardiovasc Med. 2021;8:688396 - PMID: 34458332 - PMCID: PMC8387660 - DOI: 10.3389/fcvm.2021.688396

Bartoli-Leonard F, Aikawa E

Recapitulating the Complex Pathology of Atherosclerosis: Which Model to Use?

Circ Res. 2021;129(4):491-493 - PMID: 34351800 - PMCID: PMC8352010 - DOI: 10.1161/CIRCRESAHA.121.319721

Hutcheson JD, Schlotter F, Creager MD, Li X, Pham T, Vyas P, Higashi H, Body SC, Aikawa M, Singh SA, Kos L, Aikawa E

Elastogenesis Correlates With Pigment Production in Murine Aortic Valve Leaflets.

Front Cardiovasc Med. 2021;8:678401 - PMID: 34239903 - PMCID: PMC8257952 - DOI: 10.3389/fcvm.2021.678401

Rogers MA, Aikawa E

Unbiased omics identifies mechanistic regulators of calcific aortic valve disease.

Eur Heart J. 2021;42(30):2948-2950 - PMID: 34179985 - PMCID: PMC8347449 - DOI: 10.1093/eurheartj/ehab381

Bartoli-Leonard F, Aikawa E

Old Drugs for an Old Pathology? Drug Repurposing for Calcific Aortic Valve Disease.

Circ Res. 2021;128(9):1317-1319 - PMID: 33914606 - PMCID: PMC8095786 - DOI: 10.1161/CIRCRESAHA.121.319149

Blaser MC, Kraler S, Lüscher TF, Aikawa E

Multi-Omics Approaches to Define Calcific Aortic Valve Disease Pathogenesis.

Circ Res. 2021;128(9):1371-1397 - PMID: 33914608 - PMCID: PMC8095729 - DOI: 10.1161/CIRCRESAHA.120.317979

Toyohara T, Roudnicky F, Florido MHC, Nakano T, Yu H, Katsuki S, Lee M, Meissner T, Friesen M, Davidow LS, Ptaszek L, Abe T, Rubin LL, Pereira AC, Aikawa M, Cowan CA

Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis.

Cell Stem Cell. 2020;27(1):178-180 - PMID: 32619513 - DOI: 10.1016/j.stem.2020.05.013

Passos LSA, Lupieri A, Becker-Greene D, Aikawa E

Innate and adaptive immunity in cardiovascular calcification.

Atherosclerosis. 2020;306:59-67 - PMID: 32222287 - PMCID: PMC7483874 - DOI: 10.1016/j.atherosclerosis.2020.02.016

Toyohara T, Roudnicky F, Florido MHC, Nakano T, Yu H, Katsuki S, Lee M, Meissner T, Friesen M, Davidow LS, Ptaszek L, Abe T, Rubin LL, Pereira AC, Aikawa M, Cowan CA

Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis.

Cell Stem Cell. 2020;27(1):147-157.e7 - PMID: 32413331 - PMCID: PMC8530449 - DOI: 10.1016/j.stem.2020.04.018

Watanabe Y, Takase K, Okada K, Aikawa M, Okamoto K, Koyama I

Portal vein aneurysm with complete spontaneous regression after 10 years using conservative treatment.

Clin J Gastroenterol. 2020;13(5):940-945 - PMID: 32449089 - DOI: 10.1007/s12328-020-01131-6

Kawakami R, Katsuki S, Travers R, Romero DC, Becker-Greene D, Araujo Passos LS, Higashi H, Blaser MC, Sukhova GK, Buttigieg J, Kopriva D, Schmidt AM, Anderson DG, Singh SA, Cardoso L, Weinbaum S, Libby P, Aikawa M, Croce K, Aikawa E

S100A9-RAGE Axis Accelerates Formation of Macrophage-Mediated Extracellular Vesicle Microcalcification in Diabetes Mellitus.

Arterioscler Thromb Vasc Biol. 2020;40(8):1838-1853 - PMID: 32460581 - PMCID: PMC7377960 - DOI: 10.1161/ATVBAHA.118.314087

Masoumi N, Copper D, Chen P, Cubberley A, Guo K, Lin RZ, Ahmed B, Martin D, Aikawa E, Melero-Martin J, Mayer J

Elastomeric Fibrous Hybrid Scaffold Supports In Vitro and In Vivo Tissue Formation.

Adv Funct Mater. 2017;27(27):ePub - PMID: 32863817 - PMCID: PMC7450820 - DOI: 10.1002/adfm.201606614

Nunes MCP, Levine RA, Braulio R, Pascoal-Xavier MA, Elmariah S, Gomes NFA, Soares JR, Esteves WAM, Zeng X, Dal-Bianco JP, Passos LSA, Passaglia LG, Ribeiro VT, Gelape CL, Costa PHN, Lodi-Junqueira L, Dutra W, Tan TC, Aikawa E, Hung J

Mitral Regurgitation After Percutaneous Mitral Valvuloplasty: Insights Into Mechanisms and Impact on Clinical Outcomes.

JACC Cardiovasc Imaging. 2020;13(12):2513-2526 - PMID: 32950446 - PMCID: PMC7861508 - DOI: 10.1016/j.jcmg.2020.07.020

Rogers MA, Buffolo F, Schlotter F, Atkins SK, Lee LH, Halu A, Blaser MC, Tsolaki E, Higashi H, Luther K, Daaboul G, Bouten CVC, Body SC, Singh SA, Bertazzo S, Libby P, Aikawa M, Aikawa E

Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis.

Sci Adv. 2020;6(38):ePub - PMID: 32938681 - PMCID: PMC7494353 - DOI: 10.1126/sciadv.abb1244

Figueiredo JL, Santa-Cruz F, Lima-Filho JL, Hilgendorf I, Aikawa M, Pittet MJ, Nahrendorf M, Weissleder R, Swirski FK, Robbins CS

A durable murine model of spleen transplantation with arterial and venous anastomoses.

Sci Rep. 2020;10(1):3979 - PMID: 32132617 - PMCID: PMC7055260 - DOI: 10.1038/s41598-020-60983-7

Christensen JL, Tan S, Chung HE, Ghosalkar DS, Qureshi R, Chu A, Yu W, Berus J, Shah NR, Wu WC, Chun H, Aikawa E, Choudhary G, Morrison AR

Aortic valve calcification predicts all-cause mortality independent of coronary calcification and severe stenosis.

Atherosclerosis. 2020;307:16-20 - PMID: 32702536 - PMCID: PMC7583087 - DOI: 10.1016/j.atherosclerosis.2020.06.019