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Highly Selective PPARα (Peroxisome Proliferator-Activated Receptor α) Agonist Pemafibrate Inhibits Stent Inflammation and Restenosis Assessed by Multimodality Molecular-Microstructural Imaging.
J Am Heart Assoc. 2021;10(20):e020834 - PMID: 34632804 - PMCID: PMC8751880 - DOI: 10.1161/JAHA.121.020834
A Novel Spectral Annotation Strategy Streamlines Reporting of mono-ADP-ribosylated Peptides Derived from Mouse Liver and Spleen in Response to IFN-γ.
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What Makes a Great Mentor: Interviews With Recipients of the ATVB Mentor of Women Award.
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Radiation Induces Valvular Interstitial Cell Calcific Response in an in vitro Model of Calcific Aortic Valve Disease.
Front Cardiovasc Med. 2021;8:687885 - PMID: 34527708 - PMCID: PMC8435633 - DOI: 10.3389/fcvm.2021.687885
Integration of Functional Imaging, Cytometry, and Unbiased Proteomics Reveals New Features of Endothelial-to-Mesenchymal Transition in Ischemic Mitral Valve Regurgitation in Human Patients.
Front Cardiovasc Med. 2021;8:688396 - PMID: 34458332 - PMCID: PMC8387660 - DOI: 10.3389/fcvm.2021.688396
Innate and adaptative immunity: The understudied driving force of heart valve disease.
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Recapitulating the Complex Pathology of Atherosclerosis: Which Model to Use?
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Elastogenesis Correlates With Pigment Production in Murine Aortic Valve Leaflets.
Front Cardiovasc Med. 2021;8:678401 - PMID: 34239903 - PMCID: PMC8257952 - DOI: 10.3389/fcvm.2021.678401
Unbiased omics identifies mechanistic regulators of calcific aortic valve disease.
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Old Drugs for an Old Pathology? Drug Repurposing for Calcific Aortic Valve Disease.
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Multi-Omics Approaches to Define Calcific Aortic Valve Disease Pathogenesis.
Circ Res. 2021;128(9):1371-1397 - PMID: 33914608 - PMCID: PMC8095729 - DOI: 10.1161/CIRCRESAHA.120.317979
Gene Expression Profiling Reveals the Shared and Distinct Transcriptional Signatures in Human Lung Epithelial Cells Infected With SARS-CoV-2, MERS-CoV, or SARS-CoV: Potential Implications in Cardiovascular Complications of COVID-19.
Front Cardiovasc Med. 2021;7:623012 - PMID: 33521069 - PMCID: PMC7844200 - DOI: 10.3389/fcvm.2020.623012
Nanoanalytical analysis of bisphosphonate-driven alterations of microcalcifications using a 3D hydrogel system and in vivo mouse model.
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Circulating Extracellular Vesicles As Biomarkers and Drug Delivery Vehicles in Cardiovascular Diseases.
Systems Approach to Discovery of Therapeutic Targets for Vein Graft Disease PPARα Pivotally Regulates Metabolism, Activation, and Heterogeneity of Macrophages and Lesion Development.
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ApoA-I mimetics improve aortic stenosis-associated left-ventricular diastolic dysfunction but fail to benefit rabbit models with normal aortic valves.
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Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis.
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Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling.
Rheumatic Heart Valve Disease Pathophysiology and Underlying Mechanisms.
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Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion.
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Raising awareness for rheumatic mitral valve disease.
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In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves.
JACC Basic Transl Sci. 2020;5(12):1187-1206 - PMID: 33426376 - PMCID: PMC7775962 - DOI: 10.1016/j.jacbts.2020.09.011
Calcific Aortic Valve Disease "Omics"; Is Timely, But Are We Looking Too Late?
JACC Basic Transl Sci. 2020;5(12):1178-1180 - PMID: 33427821 - PMCID: PMC7775952 - DOI: 10.1016/j.jacbts.2020.11.001
CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction.
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Metabolism of PLTP, CETP, and LCAT on multiple HDL sizes using the Orbitrap Fusion Lumos.
ApoC-III is a novel inducer of calcification in human aortic valves.
Harnessing Single-Cell RNA Sequencing to Better Understand How Diseased Cells Behave the Way They Do in Cardiovascular Disease.
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Heart Valve Disease: Challenges and New Opportunities.
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2020 Jeffrey M. Hoeg Award Lecture: Calcifying Extracellular Vesicles as Building Blocks of Microcalcifications in Cardiovascular Disorders.
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An (Auto)Taxing Effort to Mechanistically Link Obesity and Calcific Aortic Valve Disease.
JACC Basic Transl Sci. 2020;5(9):898-900 - PMID: 33016951 - PMCID: PMC7524779 - DOI: 10.1016/j.jacbts.2020.04.016
Is Toll-like receptor 4 involved in the severity of COVID-19 pathology in patients with cardiometabolic comorbidities?
Cytokine Growth Factor Rev. 2020;58:102-110 - PMID: 32988728 - PMCID: PMC7505161 - DOI: 10.1016/j.cytogfr.2020.09.002
Mitral Regurgitation After Percutaneous Mitral Valvuloplasty: Insights Into Mechanisms and Impact on Clinical Outcomes.
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The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression.
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Lipoprotein(a) and Oxidized Phospholipids Promote Valve Calcification in Patients With Aortic Stenosis.
J Am Coll Cardiol. 2019;73(17):2150-2162 - PMID: 31047003 - PMCID: PMC6494952 - DOI: 10.1016/j.jacc.2019.01.070
Standardization of Human Calcific Aortic Valve Disease in vitro Modeling Reveals Passage-Dependent Calcification.
A study into the ADP-ribosylome of IFN-γ-stimulated THP-1 human macrophage-like cells identifies ARTD8/PARP14 and ARTD9/PARP9 ADP-ribosylation.
J Proteome Res. 2019;18(4):1607-1622 - PMID: 30848916 - PMCID: PMC6456868 - DOI: 10.1021/acs.jproteome.8b00895
Editorial: Exploring the Frontiers of Regenerative Cardiovascular Medicine.
After 50 Years of Heart Transplants: What Does the Next 50 Years Hold for Cardiovascular Medicine? A Perspective From the International Society for Applied Cardiovascular Biology.
Differential miRNA Loading Underpins Dual Harmful and Protective Roles for Extracellular Vesicles in Atherogenesis.
Circ Res. 2019;124(4):467-469 - PMID: 30763209 - PMCID: PMC6383776 - DOI: 10.1161/CIRCRESAHA.119.314596
Cardiovascular calcification: artificial intelligence and big data accelerate mechanistic discovery.
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Sheep-Specific Immunohistochemical Panel for the Evaluation of Regenerative and Inflammatory Processes in Tissue-Engineered Heart Valves.
Front Cardiovasc Med. 2018;5:105 - PMID: 30159315 - PMCID: PMC6104173 - DOI: 10.3389/fcvm.2018.00105
Editorial: Extracellular Vesicle-Mediated Processes in Cardiovascular Diseases.
Front Cardiovasc Med. 2018;5:133 - PMID: 30283791 - PMCID: PMC6157324 - DOI: 10.3389/fcvm.2018.00133
Context-enriched interactome powered by proteomics helps the identification of novel regulators of macrophage activation.
XINA: A Workflow for the Integration of Multiplexed Proteomics Kinetics Data with Network Analysis.
J Proteome Res. 2018;18(2):775-781 - PMID: 30370770 - DOI: 10.1021/acs.jproteome.8b00615
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.
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