Center for Interdisciplinary Cardiovascular Sciences

Grunewald ME, Chen Y, Kuny C, Maejima T, Lease R, Ferraris D, Aikawa M, Sullivan CS, Perlman S, Fehr AR

The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression.

PLoS Pathog. 2019;15(5):e1007756 - PMID: 31095648 - PMCID: PMC6521996 - DOI: 10.1371/journal.ppat.1007756

Nakato R, Wada Y, Nakaki R, Nagae G, Katou Y, Tsutsumi S, Nakajima N, Fukuhara H, Iguchi A, Kohro T, Kanki Y, Saito Y, Kobayashi M, Izumi-Taguchi A, Osato N, Tatsuno K, Kamio A, Hayashi-Takanaka Y, Wada H, Ohta S, Aikawa M, Nakajima H, Nakamura M, McGee RC, Heppner KW, Kawakatsu T, Genno M, Yanase H, Kume H, Senbonmatsu T, Homma Y, Nishimura S, Mitsuyama T, Aburatani H, Kimura H, Shirahige K

Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells.

Epigenetics Chromatin. 2019;12(1):77 - PMID: 31856914 - PMCID: PMC6921469 - DOI: 10.1186/s13072-019-0319-0

Rogers MA, Chen J, Nallamshetty S, Pham T, Goto S, Muehlschlegel JD, Libby P, Aikawa M, Aikawa E, Plutzky J

Retinoids Repress Human Cardiovascular Cell Calcification With Evidence for Distinct Selective Retinoid Modulator Effects.

Arterioscler Thromb Vasc Biol. 2019;40(3):656-669 - PMID: 31852220 - PMCID: PMC7047603 - DOI: 10.1161/ATVBAHA.119.313366

Rogers MA, Aikawa E

MicroRNA Extracellular Vesicle Stowaways in Cell-Cell Communication and Organ Crosstalk.

Arterioscler Thromb Vasc Biol. 2019;39(12):2448-2450 - PMID: 31770027 - PMCID: PMC6980729 - DOI: 10.1161/ATVBAHA.119.313533

Arima N, Sasaki Y, Lee LH, Zhang H, Figueiredo JL, Mlynarchik AK, Qiao J, Yamada I, Higashi H, Ha AH, Halu A, Mizuno K, Singh SA, Yamazaki Y, Aikawa M

Multi-organ systems study reveals Igfbp7 as a suppressor of gluconeogenesis after gastric bypass surgery.

J Proteome Res. 2019;19(1):129-143 - PMID: 31661273 - DOI: 10.1021/acs.jproteome.9b00441

Andraski AB, Singh SA, Lee LH, Higashi H, Smith N, Zhang B, Aikawa M, Sacks FM

Effects of Replacing Dietary Monounsaturated Fat With Carbohydrate on HDL (High-Density Lipoprotein) Protein Metabolism and Proteome Composition in Humans.

Arterioscler Thromb Vasc Biol. 2019;39(11):2411-2430 - PMID: 31554421 - PMCID: PMC6874109 - DOI: 10.1161/ATVBAHA.119.312889

Aikawa M, Manabe I, Marx N

Editorial: New Trends in Vascular Inflammation Research: From Biology to Therapy.

Front Cardiovasc Med. 2019;6:102 - PMID: 31555666 - PMCID: PMC6722177 - DOI: 10.3389/fcvm.2019.00102

Atkins SK, Aikawa E

Valve under the microscope: shining a light on emerging technologies elucidating disease mechanisms.

Heart. 2019;105(21):1610-1611 - PMID: 31296591 - PMCID: PMC6855786 - DOI: 10.1136/heartjnl-2019-315236

Fruchart JC, Santos RD, Aguilar-Salinas C, Aikawa M, Al Rasadi K, Amarenco P, Barter PJ, Ceska R, Corsini A, Després JP, Duriez P, Eckel RH, Ezhov MV, Farnier M, Ginsberg HN, Hermans MP, Ishibashi S, Karpe F, Kodama T, Koenig W, Krempf M, Lim S, Lorenzatti AJ, McPherson R, Nuñez-Cortes JM, Nordestgaard BG, Ogawa H, Packard CJ, Plutzky J, Ponte-Negretti CI, Pradhan A, Ray KK, Reiner Ž, Ridker PM, Ruscica M, Sadikot S, Shimano H, Sritara P, Stock JK, Su TC, Susekov AV, Tartar A, Taskinen MR, Tenenbaum A, Tokgözoğlu LS, Tomlinson B, Tybjærg-Hansen A, Valensi P, Vrablík M, Wahli W, Watts GF, Yamashita S, Yokote K, Zambon A, Libby P

The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential : A consensus statement from the International Atherosclerosis Society (IAS) and the Residual Risk Reduction Initiative (R3i) Foundation.

Cardiovasc Diabetol. 2019;18(1):71 - PMID: 31164165 - PMCID: PMC6549355 - DOI: 10.1186/s12933-019-0864-7

Creager MD, Hohl T, Hutcheson JD, Moss AJ, Schlotter F, Blaser MC, Park MA, Lee LH, Singh SA, Alcaide-Corral CJ, Tavares AAS, Newby DE, Kijewski MF, Aikawa M, Di Carli M, Dweck MR, Aikawa E

18F-Fluoride Signal Amplification Identifies Microcalcifications Associated With Atherosclerotic Plaque Instability in Positron Emission Tomography/Computed Tomography Images.

Circ Cardiovasc Imaging. 2019;12(1):e007835 - PMID: 30642216 - PMCID: PMC6338081 - DOI: 10.1161/CIRCIMAGING.118.007835

Zheng KH, Tsimikas S, Pawade T, Kroon J, Jenkins WSA, Doris MK, White AC, Timmers NKLM, Hjortnaes J, Rogers MA, Aikawa E, Arsenault BJ, Witztum JL, Newby DE, Koschinsky ML, Fayad ZA, Stroes ESG, Boekholdt SM, Dweck MR

Lipoprotein(a) and Oxidized Phospholipids Promote Valve Calcification in Patients With Aortic Stenosis.

J Am Coll Cardiol. 2019;73(17):2150-2162 - PMID: 31047003 - PMCID: PMC6494952 - DOI: 10.1016/j.jacc.2019.01.070

Goto S, Rogers MA, Blaser MC, Higashi H, Lee LH, Schlotter F, Body SC, Aikawa M, Singh SA, Aikawa E

Standardization of Human Calcific Aortic Valve Disease in vitro Modeling Reveals Passage-Dependent Calcification.

Front Cardiovasc Med. 2019;6:49 - PMID: 31041314 - PMCID: PMC6476921 - DOI: 10.3389/fcvm.2019.00049

Higashi H, Maejima T, Lee LH, Yamazaki Y, Hottiger MO, Singh SA, Aikawa M

A study into the ADP-ribosylome of IFN-γ-stimulated THP-1 human macrophage-like cells identifies ARTD8/PARP14 and ARTD9/PARP9 ADP-ribosylation.

J Proteome Res. 2019;18(4):1607-1622 - PMID: 30848916 - PMCID: PMC6456868 - DOI: 10.1021/acs.jproteome.8b00895

Phillippi JA, Aikawa E, Hutcheson J

Editorial: Exploring the Frontiers of Regenerative Cardiovascular Medicine.

Front Cardiovasc Med. 2019;6:13 - PMID: 30873414 - PMCID: PMC6401650 - DOI: 10.3389/fcvm.2019.00013

Hutcheson JD, Goergen CJ, Schoen FJ, Aikawa M, Zilla P, Aikawa E, Gaudette GR

After 50 Years of Heart Transplants: What Does the Next 50 Years Hold for Cardiovascular Medicine? A Perspective From the International Society for Applied Cardiovascular Biology.

Front Cardiovasc Med. 2019;6:8 - PMID: 30838213 - PMCID: PMC6382669 - DOI: 10.3389/fcvm.2019.00008

Blaser MC, Aikawa E

Differential miRNA Loading Underpins Dual Harmful and Protective Roles for Extracellular Vesicles in Atherogenesis.

Circ Res. 2019;124(4):467-469 - PMID: 30763209 - PMCID: PMC6383776 - DOI: 10.1161/CIRCRESAHA.119.314596

Kovacic JC, Dimmeler S, Harvey RP, Finkel T, Aikawa E, Krenning G, Baker AH

Endothelial to Mesenchymal Transition in Cardiovascular Disease: JACC State-of-the-Art Review.

J Am Coll Cardiol. 2019;73(2):190-209 - PMID: 30654892 - PMCID: PMC6865825 - DOI: 10.1016/j.jacc.2018.09.089