Goettsch, Claudia
Dr. Claudia Goettsch studied nutrition sciences at the University of Jena (Germany), and did her PhD thesis in the Department of Vascular Endothelium and Microcirculation at the Medical Faculty of the University of Technology Dresden , Germany. During this time she studied different NADPH oxidase (Nox) isoforms as potential molecular sources of reactive oxygen species in human endothelial cells. Dr. Goettsch was enrolled at the PhD program “Metabolism and Endothelium” of the Dresden Medical Faculty and finished her PhD thesis “Regulation of oxidative stress by biomechanical forces and high-fat diet in the cardiovascular system” in 2007.
She was awarded the Carl GustavCarus Award for the best PhD thesis in 2007.
Dr. Goettsch did her first postdoc in the bone vascular lab of Prof. Lorenz Hofbauer (Dresden, Germany). There she systematically extended her research and knowledge from vascular biology to bone metabolism.The major scientific goal and interest was to uncover the mechanisms underlying the arterial calcification-osteoporosis syndrome, which is of key interest given the high coincidence of osteoporosis and vascular calcification in the aging population. As part of that research she focused on oxidative stress, in particular stress cause by oxidized lipoproteins, and investigated the role of NFATs and miRNAs during osteogenic processes within the vascular wall. In 2009 Dr. Goettsch was given a Research Award “Dresdner Cardiovascular Days” (Germany) and she received a Young Investigator Award from the American Society for Bone and Mineral Research (ASBMR). Her work on miRNAs in calcification processes received the Young Investigator Award of the German Bone Society.
Dr. Goettsch has been a postdoctoral research fellow at CICS since June 2011. She focuses primarily on the identification of common mediators and mechanisms of both arterial calcification and bone remodeling. Dr. Goettsch’s major scientific goal is to identify targets which prevent cardiovascular calcification.
Publications
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Goettsch C, Kjolby M, Aikawa E
Sortilin and Its Multiple Roles in Cardiovascular and Metabolic Diseases.
Rogers M, Maldonado-Martinez N, Hutcheson JD, Goettsch C, Goto S, Yamada I, Faits T, Sesaki H, Aikawa M, Aikawa E
Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress.
Goettsch C, Iwata H, Hutcheson JD, O'Donnell CJ, Chapurlat R, Cook NR, Aikawa M, Szulc P, Aikawa E
Serum Sortilin Associates With Aortic Calcification and Cardiovascular Risk in Men.
Iwata H, Goettsch C, Sharma A, Ricchiuto P, Goh WW, Halu A, Yamada I, Yoshida H, Hara T, Wei M, Inoue N, Fukuda D, Mojcher A, Mattson PC, Barabási AL, Boothby M, Aikawa E, Singh SA, Aikawa M
PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation.
Kramann R, Goettsch C, Wongboonsin J, Iwata H, Schneider RK, Kuppe C, Kaesler N, Chang-Panesso M, Machado FG, Gratwohl S, Madhurima K, Hutcheson JD, Jain S, Aikawa E, Humphreys BD
Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease.
Goettsch C, Hutcheson JD, Hagita S, Rogers MA, Creager MD, Pham T, Choi J, Mlynarchik AK, Pieper B, Kjolby M, Aikawa M, Aikawa E
A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification.
Hjortnaes J, Goettsch C, Hutcheson JD, Camci-Unal G, Lax L, Scherer K, Body S, Schoen FJ, Kluin J, Khademhosseini A, Aikawa E
Simulation of early calcific aortic valve disease in a 3D platform: A role for myofibroblast differentiation.
Goettsch C, Hutcheson JD, Aikawa M, Iwata H, Pham T, Nykjaer A, Kjolby M, Rogers M, Michel T, Shibasaki M, Hagita S, Kramann R, Rader DJ, Libby P, Singh SA, Aikawa E
Sortilin mediates vascular calcification via its recruitment into extracellular vesicles.
Hutcheson JD, Goettsch C, Bertazzo S, Maldonado N, Ruiz JL, Goh W, Yabusaki K, Faits T, Bouten C, Franck G, Quillard T, Libby P, Aikawa M, Weinbaum S, Aikawa E
Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques.
Shibasaki M, Wang JG, Figueiredo JL, New SE, Quillard T, Goettsch C, Koga JI, Sonoki H, Matsumoto J, Aikawa M, Aikawa E
Pitavastatin Reduces Inflammation in Atherosclerotic Plaques in Apolipoprotein E-Deficient Mice with Late Stage Renal Disease.
Hutcheson JD, Goettsch C, Rogers MA, Aikawa E
Revisiting Cardiovascular Calcification: A Multifaceted Disease Requiring a Multidisciplinary Approach.
Hjortnaes J, Shapero K, Goettsch C, Hutcheson JD, Keegan J, Kluin J, Mayer JE, Bischoff J, Aikawa E
Valvular interstitial cells suppress calcification of valvular endothelial cells.
Hutcheson JD, Goettsch C, Pham T, Iwashita M, Aikawa M, Singh SA, Aikawa E
Enrichment of calcifying extracellular vesicles using density-based ultracentrifugation protocol.
Goettsch C, Iwata H, Aikawa E
Parathyroid hormone: critical bridge between bone metabolism and cardiovascular disease.
Itou T, Maldonado N, Yamada I, Goettsch C, Matsumoto J, Aikawa M, Singh S, Aikawa E
Cystathionine γ-lyase Accelerates Osteoclast Differentiation: Identification of a Novel Regulator of Osteoclastogenesis by Proteomic Analysis.
Rogers M, Goettsch C, Aikawa E
Medial and intimal calcification in chronic kidney disease: stressing the contributions.
New SE, Goettsch C, Aikawa M, Marchini JF, Shibasaki M, Yabusaki K, Libby P, Shanahan CM, Croce K, Aikawa E
Macrophage-Derived Matrix Vesicles: An Alternative Novel Mechanism for Microcalcification in Atherosclerotic Plaques.
Goettsch C, Hutcheson JD, Aikawa E
MicroRNA in Cardiovascular Calcification: Focus on Targets and Extracellular Vesicle Delivery Mechanisms.
Goettsch C, Rauner M, Sinningen K, Helas S, Al-Fakhri N, Nemeth K, Hamann C, Kopprasch S, Aikawa E, Bornstein SR, Schoppet M, Hofbauer LC
The osteoclast-associated receptor (OSCAR) is a novel receptor regulated by oxidized low-density lipoprotein in human endothelial cells.
Goettsch C, Rauner M, Pacyna N, Hempel U, Bornstein SR, Hofbauer LC
miR-125b regulates calcification of vascular smooth muscle cells.
Goettsch C, Rauner M, Hamann C, Sinningen K, Hempel U, Bornstein SR, Hofbauer LC
Nuclear factor of activated T cells mediates oxidised LDL-induced calcification of vascular smooth muscle cells.
Thiele S, Rauner M, Goettsch C, Rachner TD, Benad P, Fuessel S, Erdmann K, Hamann C, Baretton GB, Wirth MP, Jakob F, Hofbauer LC
Expression profile of WNT molecules in prostate cancer and its regulation by aminobisphosphonates.
Goettsch C, Goettsch W, Brux M, Haschke C, Brunssen C, Muller G, Bornstein SR, Duerrschmidt N, Wagner AH, Morawietz H
Arterial flow reduces oxidative stress via an antioxidant response element and Oct-1 binding site within the NADPH oxidase 4 promoter in endothelial cells.
Nemeth K, Schoppet M, Al-Fakhri N, Helas S, Jessberger R, Hofbauer LC, Goettsch C
The role of osteoclast-associated receptor in osteoimmunology.
Rauner M, Goettsch C, Stein N, Thiele S, Bornhaeuser M, De Bosscher K, Haegeman G, Tuckermann J, Hofbauer LC
Dissociation of osteogenic and immunological effects by the selective glucocorticoid receptor agonist, compound A, in human bone marrow stromal cells.
Lutter AH, Hempel U, Wolf-Brandstetter C, Garbe AI, Goettsch C, Hofbauer LC, Jessberger R, Dieter P
A novel resorption assay for osteoclast functionality based on an osteoblast-derived native extracellular matrix.
Goettsch C, Goettsch W, Arsov A, Hofbauer LC, Bornstein SR, Morawietz H
Long-term cyclic strain downregulates endothelial Nox4.
Rachner TD, Benad P, Rauner M, Goettsch C, Singh SK, Schoppet M, Hofbauer LC
Osteoprotegerin production by breast cancer cells is suppressed by dexamethasone and confers resistance against TRAIL-induced apoptosis.
Helas S, Goettsch C, Schoppet M, Zeitz U, Hempel U, Morawietz H, Kostenuik PJ, Erben RG, Hofbauer LC
Inhibition of receptor activator of NF-kappaB ligand by denosumab attenuates vascular calcium deposition in mice.
Goettsch C, Goettsch W, Muller G, Seebach J, Schnittler HJ, Morawietz H
Nox4 overexpression activates reactive oxygen species and p38 MAPK in human endothelial cells.
Rauner M, Sipos W, Goettsch C, Wutzl A, Foisner R, Pietschmann P, Hofbauer LC
Inhibition of lamin A/C attenuates osteoblast differentiation and enhances RANKL-dependent osteoclastogenesis.
Xu H, Goettsch C, Xia N, Horke S, Morawietz H, Förstermann U, Li H
Differential roles of PKCalpha and PKCepsilon in controlling the gene expression of Nox4 in human endothelial cells.
Goettsch W, Gryczka C, Korff T, Ernst E, Goettsch C, Seebach J, Schnittler HJ, Augustin HG, Morawietz H
Flow-dependent regulation of angiopoietin-2.
Muller G, Goettsch C, Morawietz H
Oxidative stress and endothelial dysfunction.
Hamostaseologie. 2007;27(1):5-12 - PMID:
17279271