Yamada, Iwao
In 1996, Mr. Iwao Yamada enrolled to obtain a Masters degree in the Department of Applied Chemistry, Faculty of Science and Technology, Keio University in Japan. He learned organic synthetic skills along with separation and purification techniques of organic compounds as well as analytical skills using 1H-/13C-NMR.
After graduating in 1998, Mr. Yamada started to work in an ADME group within the ADME department, Tokyo New Drug Research Laboratories, Kowa Company, Ltd. in Japan and, in 2007, became a Chief Lab Researcher. He utilized LC/MS/MS techniques to determine drug concentrations in animal plasma to estimate exposure levels to assure that these drugs would be safe for use in humans. He also gained experience in using in vivo animal absorption studies. In 2010, he began to work with the atherosclerosis research group in the pharmacology department and received training in pharmacology and biology research techniques.
Mr. Yamada joined the CICS in May 2011. Since then he has been conducting experiments about the signaling pathway of endothelial lipase and inhibition of this pathway by pitavastatin, to determine whether this inhibition will lead to increased HDL levels in human plasma.
Mr. Yamada’s personal goal in the next phase of his career is to obtain a Ph.D. degree in pharmacology and to have the skills necessary to become a scientific generalist with the tools to develop new drugs efficiently.
Publications
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Arima N, Sasaki Y, Lee LH, Zhang H, Figueiredo JL, Mlynarchik AK, Qiao J, Yamada I, Higashi H, Ha AH, Halu A, Mizuno K, Singh SA, Yamazaki Y, Aikawa M
Multi-organ systems study reveals Igfbp7 as a suppressor of gluconeogenesis after gastric bypass surgery.
Rogers M, Maldonado-Martinez N, Hutcheson JD, Goettsch C, Goto S, Yamada I, Faits T, Sesaki H, Aikawa M, Aikawa E
Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress.
Iwata H, Goettsch C, Sharma A, Ricchiuto P, Goh WW, Halu A, Yamada I, Yoshida H, Hara T, Wei M, Inoue N, Fukuda D, Mojcher A, Mattson PC, Barabási AL, Boothby M, Aikawa E, Singh SA, Aikawa M
PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation.
Ricchiuto P, Iwata H, Yabusaki K, Yamada I, Pieper B, Sharma A, Aikawa M, Singh SA
mIMT-visHTS: A novel method for multiplexing isobaric mass tagged datasets with an accompanying visualization high throughput screening tool for protein profiling.
Itou T, Maldonado N, Yamada I, Goettsch C, Matsumoto J, Aikawa M, Singh S, Aikawa E
Cystathionine γ-lyase Accelerates Osteoclast Differentiation: Identification of a Novel Regulator of Osteoclastogenesis by Proteomic Analysis.
Fujino H, Yamada I, Shimada S, Kojima J
Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase--effect of cMOAT deficiency on hepatobiliary excretion in rats and of mdr1a/b gene disruption on tissue distribution in mice.
Fujino H, Yamada I, Shimada S, Hirano M, Tsunenari Y, Kojima J
Interaction between fibrates and statins--metabolic interactions with gemfibrozil.
Fujino H, Shimada S, Yamada I, Hirano M, Tsunenari Y, Kojima J
Studies on the interaction between fibrates and statins using human hepatic microsomes.
Yamada I, Fujino H, Shimada S, Kojima J
Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase: similarities and difference in the metabolism of pitavastatin in monkeys and humans.
Fujino H, Yamada I, Shimada S, Yoneda M, Kojima J
Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase: human UDP-glucuronosyltransferase enzymes involved in lactonization.
Fujino H, Yamada I, Shimada S, Nagao T, Yoneda M
Metabolic fate of pitavastatin (NK-104), a new inhibitor of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase. Effects on drug-metabolizing systems in rats and humans.
Suzuki T, Suzuki ST, Yamada I, Koashi Y, Yamada K, Chida N
Total synthesis of spicamycin.
Fujino H, Yamada I, Shimada S, Yoneda M
Simultaneous determination of taxol and its metabolites in microsomal samples by a simple thin-layer chromatography radioactivity assay--inhibitory effect of NK-104, a new inhibitor of HMG-CoA reductase.
Suzuki T, Tanaka S, Yamada I, Koashi Y, Yamada K, Chida N
Total synthesis of spicamycin amino nucleoside.
Chida N, Suzuki T, Tanaka S, Yamada I
Pd-Catalyzed coupling reaction of glycosylamines with 6-chloropurines. Synthesis of 6-(β-mannopyranosylamino)-9H-purine and its β- -gluco isomer, N-glycoside models for spicamycin and septacidin.
Tetrahedron Lett. 1999;40:2573-6
Fujino H, Yamada I, Kojima J, Hirano H, Matsumoto H, Yoneda M
Studies on the Metabolic Fate of NK-104, a New Inhibitor of HMG-CoA Reductase(5). In Vitro Metabolism and Plasma Protein Binding in Animals and Human.
Xenobio Metab Disp. 1999;14:415-24