Wang, Jianguo
Dr. Wang obtained his Ph.D. at Shanghai Institute of Biochemistry and Cell Biology in 2003. In the past 9 years, his research has been focusing on the biology of Tissue Factor(TF) and roles of Microparticles(MPs) in thrombosis and inflammation.
Dr. Wang competed his first postdoc training in Professor Arne Slungaard’s laboratory in Department of medicine at University of Minnesota (2003-2007). He found that HOSCN is a potent inducer of endothelial cell TF and several important cell adhesion molecules expression through the activation of NF-κB and Erk-Egr-1 signaling pathways. He also discovered that histone deacetylase-3(HDAC3) plays a critical role in regulating TFgene expression in cultured endothelial cells and monocytes.
Dr. Wang joined Dr. Nigel Mackman’s research group at University of North Carolina-Chapel Hill in 2007. He developed and validated a novel method to measure the levels of microparticle(MP) TF activity in plasma from human and mouse. He found that plasma level of TF-positive MPs correlates with the activation of coagulation in endotoxemic mice and may be a potential biomarker associated with the risk of venous thromboembolism in patients with pancreatic cancer. In an orthotopicmouse model of pancreatic cancer, he found that tumor-derived TF drives the coagulation activation and tumors are the major source of TF-positive MP in the plasma from tumor-bearing mice. In addition, He found that monocytic MPs activate endothelial cells by an IL-1β-dependent mechanism. Dr. Wang received Pier M. Mannucci Young Investigator Award from the International Society of Thrombosis and Haemostasis in 2010.
Dr. Wang joined the Center for Interdisciplinary Cardiovascular Sciences in August 2012. He is investigating the roles of long noncoding RNAs(lncRNAs) in macrophage differentiation and polarization. His major scientific goal is to identify novel lncRNAs as the potential therapeutic targets in cardiovascular diseases.
Publications
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Halu A, Wang JG, Iwata H, Mojcher A, Abib AL, Singh SA, Aikawa M, Sharma A
Context-enriched interactome powered by proteomics helps the identification of novel regulators of macrophage activation.
Sun X, Haas ME, Miao J, Mehta A, Graham MJ, Crooke RM, de Barros JP, Wang JG, Aikawa M, Masson D, Biddinger SB
Insulin dissociates the effects of Liver X Receptor on lipogenesis, endoplasmic reticulum stress and inflammation.
Wang JG, Aikawa M
Toll-Like Receptors and Src-Family Kinases in Atherosclerosis - Focus on Macrophages.
Shibasaki M, Wang JG, Figueiredo JL, New SE, Quillard T, Goettsch C, Koga JI, Sonoki H, Matsumoto J, Aikawa M, Aikawa E
Pitavastatin Reduces Inflammation in Atherosclerotic Plaques in Apolipoprotein E-Deficient Mice with Late Stage Renal Disease.
Wang JG, Aikawa E, Aikawa M
Leukocyte-derived Microparticles as Pro-inflammatory Mediators in Atherosclerosis.
Chantrathammachart P, Mackman N, Sparkenbaugh E, Wang JG, Parise LV, Kirchhofer D, Key NS, Pawlinski R
Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease.
Wang JG, Geddings JE, Aleman MM, Cardenas JC, Chantrathammachart P, Williams JC, Kirchhofer D, Bogdanov VY, Bach RR, Rak J, Church FC, Wolberg AS, Pawlinski R, Key NS, Yeh JJ, Mackman N
Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer.
Owens AP, Passam FH, Antoniak S, Marshall SM, McDaniel AL, Rudel L, Williams JC, Hubbard BK, Dutton JA, Wang J, Tobias PS, Curtiss LK, Daugherty A, Kirchhofer D, Luyendyk JP, Moriarty PM, Nagarajan S, Furie BC, Furie B, Johns DG, Temel RE, Mackman N
Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin.
Hampton AL, Diaz JA, Hawley AE, Wrobleski SK, Wang JG, Lee RD, Kirchhofer D, Sigler RE, Wakefield TW, Mackman N, Myers DD
Myeloid cell tissue factor does not contribute to venous thrombogenesis in an electrolytic injury model.
Cronan MR, Nakamura K, Johnson NL, Granger DA, Cuevas BD, Wang JG, Mackman N, Scott JE, Dohlman HG, Johnson GL
Defining MAP3 kinases required for MDA-MB-231 cell tumor growth and metastasis.
Boles JC, Williams JC, Hollingsworth RM, Wang JG, Glover SL, Owens AP, Barcel DA, Kasthuri RS, Key NS, Mackman N
Anthracycline treatment of the human monocytic leukemia cell line THP-1 increases phosphatidylserine exposure and tissue factor activity.
Lee RD, Barcel DA, Williams JC, Wang JG, Boles JC, Manly DA, Key NS, Mackman N
Pre-analytical and analytical variables affecting the measurement of plasma-derived microparticle tissue factor activity.
Wang JG, Williams JC, Davis BK, Jacobson K, Doerschuk CM, Ting JP, Mackman N
Monocytic microparticles activate endothelial cells in an IL-1β-dependent manner.
Mukherjee SD, Swystun LL, Mackman N, Wang JG, Pond G, Levine MN, Liaw PC
Impact of chemotherapy on thrombin generation and on the protein C pathway in breast cancer patients.
Li F, Wang CH, Wang JG, Thai T, Boysen G, Xu L, Turner AL, Wolberg AS, Mackman N, Maeda N, Takahashi N
Elevated tissue factor expression contributes to exacerbated diabetic nephropathy in mice lacking eNOS fed a high fat diet.
Pawlinski R, Wang JG, Owens AP, Williams J, Antoniak S, Tencati M, Luther T, Rowley JW, Low EN, Weyrich AS, Mackman N
Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice.
Zhang W, Wang J, Wang H, Tang R, Belcher JD, Viollet B, Geng JG, Zhang C, Wu C, Slungaard A, Zhu C, Huo Y
Acadesine inhibits tissue factor induction and thrombus formation by activating the phosphoinositide 3-kinase/Akt signaling pathway.
Manly DA, Wang J, Glover SL, Kasthuri R, Liebman HA, Key NS, Mackman N
Increased microparticle tissue factor activity in cancer patients with Venous Thromboembolism.
Wang JG, Manly D, Kirchhofer D, Pawlinski R, Mackman N
Levels of microparticle tissue factor activity correlate with coagulation activation in endotoxemic mice.
Ollivier V, Wang J, Manly D, Machlus KR, Wolberg AS, Jandrot-Perrus M, Mackman N
Detection of endogenous tissue factor levels in plasma using the calibrated automated thrombogram assay.
Li YD, Ye BQ, Zheng SX, Wang JT, Wang JG, Chen M, Liu JG, Pei XH, Wang LJ, Lin ZX, Gupta K, Mackman N, Slungaard A, Key NS, Geng JG
NF-kappaB transcription factor p50 critically regulates tissue factor in deep vein thrombosis.
Khorana AA, Francis CW, Menzies KE, Wang JG, Hyrien O, Hathcock J, Mackman N, Taubman MB
Plasma tissue factor may be predictive of venous thromboembolism in pancreatic cancer.
Wang J, Mahmud SA, Bitterman PB, Huo Y, Slungaard A
Histone deacetylase inhibitors suppress TF-kappaB-dependent agonist-driven tissue factor expression in endothelial cells and monocytes.
Wang JG, Mahmud SA, Nguyen J, Slungaard A
Thiocyanate-dependent induction of endothelial cell adhesion molecule expression by phagocyte peroxidases: a novel HOSCN-specific oxidant mechanism to amplify inflammation.
Wang J, Slungaard A
Role of eosinophil peroxidase in host defense and disease pathology.
Wang JG, Mahmud SA, Thompson JA, Geng JG, Key NS, Slungaard A
The principal eosinophil peroxidase product, HOSCN, is a uniquely potent phagocyte oxidant inducer of endothelial cell tissue factor activity: a potential mechanism for thrombosis in eosinophilic inflammatory states.
Xia YF, Ye BQ, Li YD, Wang JG, He XJ, Lin X, Yao X, Ma D, Slungaard A, Hebbel RP, Key NS, Geng JG
Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50.
Wang JG, Geng JG
Affinity and kinetics of P-selectin binding to heparin.
Wang J, Mu JS, Zhu HS, Geng JG
N-desulfated non-anticoagulant heparin inhibits leukocyte adhesion and transmigration in vitro and attenuates acute peritonitis and ischemia and reperfusion injury in vivo.
