Turner, Mandy E.M.
Dr. Mandy Turner is a Research Fellow at the Center for Interdisciplinary Cardiovascular Sciences in the Cardiovascular Division of Brigham and Women’s Hospital and Harvard Medical School. She obtained her Bachelor of Science in Life Sciences and Mathematics (2015) from Queen’s University in Kingston, Ontario, Canada. She completed her PhD in Pharmacology and Toxicology (2021) under the supervision of Drs. Michael Adams and Rachel Holden, where she was a Canadian Institutes of Health Research (CIHR) Vanier Scholar. Her translational doctoral research focused on aberrant phosphate metabolism in chronic kidney disease and subsequent medial vascular calcification utilizing animal and human experiments, leading to the development of a novel diagnostic phosphate metabolism tool.
She joined CICS in 2021 as a postdoctoral research fellow under the mentorship of Professor Elena Aikawa as a CIHR Banting Fellow. She is using proteomic techniques and molecular and extracellular vesicle approaches to study cardiovascular calcification, specifically i) the role of post-translational gamma carboxylation in calcific aortic valve disease and ii) calcific lesion subtyping in peripheral arterial disease.
Dr. Turner is the recipient of the 2023-2024 Richard Gorlin Fellowship in Cardiovascular Medicine at Brigham and Women’s Hospital.
Publications
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Raju S, Turner ME, Cao C, Abdul-Samad M, Punwasi N, Blaser MC, Cahalane RM, Botts SR, Prajapati K, Patel S, Wu R, Gustafson D, Galant NJ, Fiddes L, Chemaly M, Hedin U, Matic L, Seidman M, Subasri V, Singh SA, Aikawa E, Fish JE, Howe KL
Multi-omic Landscape of Extracellular Vesicles in Human Carotid Atherosclerotic Plaque Reveals Endothelial Communication Networks.
Cahalane RME, Turner ME, Clift CL, Blaser MC, Bogut G, Levy S, Kasai T, Driedonks TAP, Nolte-'t Hoen ENM, Aikawa M, Singh SA, Aikawa E
Polycarbonate Ultracentrifuge Tube Re-use in Proteomic Analyses of Extracellular Vesicles.
Clift CL, Blaser MC, Gerrits W, Turner ME, Sonawane A, Pham T, Andresen JL, Fenton OS, Grolman JM, Campedelli A, Buffolo F, Schoen FJ, Hjortnaes J, Muehlschlegel JD, Mooney DJ, Aikawa M, Singh SA, Langer R, Aikawa E
Intracellular proteomics and extracellular vesiculomics as a metric of disease recapitulation in 3D-bioprinted aortic valve arrays.
Turner ME, Beck L, Hill Gallant KM, Chen Y, Moe OW, Kuro-O M, Moe S, Aikawa E
Phosphate in Cardiovascular Disease: From New Insights Into Molecular Mechanisms to Clinical Implications.
Turner ME, Aikawa E
Updating the paradigm: inflammation as a targetable modulator of medial vascular calcification.
Blaser MC, Buffolo F, Halu A, Turner ME, Schlotter F, Higashi H, Pantano L, Clift CL, Saddic LA, Atkins SK, Rogers MA, Pham T, Vromman A, Shvartz E, Sukhova GK, Monticone S, Camussi G, Robson SC, Body SC, Muehlschlegel JD, Singh SA, Aikawa M, Aikawa E
Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis.
Bartoli-Leonard F, Chelvanambi S, Pham T, Turner ME, Blaser MC, Caputo M, Aikawa M, Pang A, Muehlschlegel J, Aikawa E
Single-cell T cell receptor sequencing of paired tissue and blood samples reveals clonal expansion of CD8+ effector T cells in patients with calcific aortic valve disease.
Bartoli-Leonard F, Zimmer J, Sonawane AR, Perez K, Turner ME, Kuraoka S, Pham T, Li F, Aikawa M, Singh S, Brewster L, Aikawa E
NLRP3 Inflammasome Activation in Peripheral Arterial Disease.
Bartoli-Leonard F, Turner ME, Zimmer J, Chapurlat R, Pham T, Aikawa M, Pradhan AD, Szulc P, Aikawa E
Elevated lipoprotein(a) as a predictor for coronary events in older men.
