Enomoto, Takashi
Dr. Takashi Enomoto majored in biological science with a concentration in cell and developmental biology in Osaka University. After graduation, Dr. Enomoto has been working at Tokyo New Drug Research Laboratory, Kowa Company, Ltd. He worked for screening new drugs to treat atherosclerosis. In Nagoya University, Dr. Enomoto belonged to the cardiology laboratory to study novel adipocytokines, and acquired Ph.D of medicine. He currently engaged in the project of screening drugs to treat sarcopenia (a muscle wasting disease) at Tokyo New Drug Research Laboratory, Kowa Company, Ltd.
Publications
ShowOgawa H, Ohashi K, Ito M, Shibata R, Kanemura N, Yuasa D, Kambara T, Matsuo K, Hayakawa S, Hiramatsu-Ito M, Otaka N, Kawanishi H, Yamaguchi S, Enomoto T, Abe T, Kaneko M, Takefuji M, Murohara T, Ouchi N
Adipolin/CTRP12 protects against pathological vascular remodeling through suppression of smooth muscle cell growth and macrophage inflammatory response.
Cardiovasc Res. 2019;116(1):237-249 - PMID: 30874788 - DOI: 10.1093/cvr/cvz074
Otaka N, Shibata R, Ohashi K, Uemura Y, Kambara T, Enomoto T, Ogawa H, Ito M, Kawanishi H, Maruyama S, Joki Y, Fujikawa Y, Narita S, Unno K, Kawamoto Y, Murate T, Murohara T, Ouchi N
Myonectin Is an Exercise-Induced Myokine That Protects the Heart From Ischemia-Reperfusion Injury.
Circ Res. 2018;123(12):1326-1338 - PMID: 30566056 - DOI: 10.1161/CIRCRESAHA.118.313777
Kanemura N, Shibata R, Ohashi K, Ogawa H, Hiramatsu-Ito M, Enomoto T, Yuasa D, Ito M, Hayakawa S, Otaka N, Murohara T, Ouchi N
C1q/TNF-related protein 1 prevents neointimal formation after arterial injury.
Atherosclerosis. 2017;257:138-145 - PMID: 28131048 - DOI: 10.1016/j.atherosclerosis.2017.01.014
Koura M, Yamaguchi Y, Kurobuchi S, Sumida H, Watanabe Y, Enomoto T, Matsuda T, Okuda A, Koshizawa T, Matsumoto Y, Shibuya K
Discovery of a 2-hydroxyacetophenone derivative as an outstanding linker to enhance potency and β-selectivity of liver X receptor agonist.
Bioorg Med Chem. 2016;24(16):3436-46 - PMID: 27283790 - DOI: 10.1016/j.bmc.2016.05.048
Hiramatsu-Ito M, Shibata R, Ohashi K, Uemura Y, Kanemura N, Kambara T, Enomoto T, Yuasa D, Matsuo K, Ito M, Hayakawa S, Ogawa H, Otaka N, Kihara S, Murohara T, Ouchi N
Omentin attenuates atherosclerotic lesion formation in apolipoprotein E-deficient mice.
Cardiovasc Res. 2015;110(1):107-17 - PMID: 26714927 - DOI: 10.1093/cvr/cvv282
Kambara T, Shibata R, Ohashi K, Matsuo K, Hiramatsu-Ito M, Enomoto T, Yuasa D, Ito M, Hayakawa S, Ogawa H, Aprahamian T, Walsh K, Murohara T, Ouchi N
C1q/Tumor Necrosis Factor-Related Protein 9 Protects against Acute Myocardial Injury through an Adiponectin Receptor I-AMPK-Dependent Mechanism.
Kambara T, Shibata R, Ohashi K, Matsuo K, Hiramatsu-Ito M, Enomoto T, Yuasa D, Ito M, Hayakawa S, Ogawa H, Aprahamian T, Walsh K, Murohara T, Ouchi N
C1q/Tumor Necrosis Factor-Related Protein 9 Protects against Acute Myocardial Injury through an Adiponectin Receptor I-AMPK-Dependent Mechanism.
Matsuo K, Shibata R, Ohashi K, Kambara T, Uemura Y, Hiramatsu-Ito M, Enomoto T, Yuasa D, Joki Y, Ito M, Hayakawa S, Ogawa H, Kihara S, Murohara T, Ouchi N
Omentin functions to attenuate cardiac hypertrophic response.
J Mol Cell Cardiol. 2014;79:195-202 - PMID: 25479337 - DOI: 10.1016/j.yjmcc.2014.11.019
Uemura Y, Shibata R, Kanemura N, Ohashi K, Kambara T, Hiramatsu-Ito M, Enomoto T, Yuasa D, Joki Y, Matsuo K, Ito M, Hayakawa S, Ogawa H, Murohara T, Ouchi N
Adipose-derived protein omentin prevents neointimal formation after arterial injury.
FASEB J. 2014;29(1):141-51 - PMID: 25300621 - DOI: 10.1096/fj.14-258129
Hayakawa S, Ohashi K, Shibata R, Kataoka Y, Miyabe M, Enomoto T, Joki Y, Shimizu Y, Kambara T, Uemura Y, Yuasa D, Ogawa H, Matsuo K, Hiramatsu-Ito M, van den Hoff MJ, Walsh K, Murohara T, Ouchi N
Cardiac myocyte-derived follistatin-like 1 prevents renal injury in a subtotal nephrectomy model.
J Am Soc Nephrol. 2014;26(3):636-46 - PMID: 25071081 - PMCID: PMC4341480 - DOI: 10.1681/ASN.2014020210
Kataoka Y, Shibata R, Ohashi K, Kambara T, Enomoto T, Uemura Y, Ogura Y, Yuasa D, Matsuo K, Nagata T, Oba T, Yasukawa H, Numaguchi Y, Sone T, Murohara T, Ouchi N
Omentin prevents myocardial ischemic injury through AMP-activated protein kinase- and Akt-dependent mechanisms.
J Am Coll Cardiol. 2014;63(24):2722-33 - PMID: 24768874 - DOI: 10.1016/j.jacc.2014.03.032
Miyabe M, Ohashi K, Shibata R, Uemura Y, Ogura Y, Yuasa D, Kambara T, Kataoka Y, Yamamoto T, Matsuo K, Joki Y, Enomoto T, Hayakawa S, Hiramatsu-Ito M, Ito M, Van Den Hoff MJ, Walsh K, Murohara T, Ouchi N
Muscle-derived follistatin-like 1 functions to reduce neointimal formation after vascular injury.
Ohashi K, Enomoto T, Joki Y, Shibata R, Ogura Y, Kataoka Y, Shimizu Y, Kambara T, Uemura Y, Yuasa D, Matsuo K, Hayakawa S, Hiramatsu-Ito M, Murohara T, Ouchi N
Neuron-derived neurotrophic factor functions as a novel modulator that enhances endothelial cell function and revascularization processes.
J Biol Chem. 2014;289(20):14132-44 - PMID: 24706764 - PMCID: PMC4022881 - DOI: 10.1074/jbc.M114.555789
Enomoto T, Ohashi K, Shibata R, Kambara T, Uemura Y, Yuasa D, Kataoka Y, Miyabe M, Matsuo K, Joki Y, Hayakawa S, Hiramatsu-Ito M, Ito M, Murohara T, Ouchi N
Transcriptional regulation of an insulin-sensitizing adipokine adipolin/CTRP12 in adipocytes by Krüppel-like factor 15.
PLOS One. 2013;8(12):e83183 - PMID: 24358263 - PMCID: PMC3865152 - DOI: 10.1371/journal.pone.0083183
Enomoto T, Shibata R, Ohashi K, Kambara T, Kataoka Y, Uemura Y, Yuasa D, Murohara T, Ouchi N
Regulation of adipolin/CTRP12 cleavage by obesity.
Biochem Biophys Res Commun. 2012;428(1):155-9 - PMID: 23068097 - DOI: 10.1016/j.bbrc.2012.10.031
Uemura Y, Shibata R, Ohashi K, Enomoto T, Kambara T, Yamamoto T, Ogura Y, Yuasa D, Joki Y, Matsuo K, Miyabe M, Kataoka Y, Murohara T, Ouchi N
Adipose-derived factor CTRP9 attenuates vascular smooth muscle cell proliferation and neointimal formation.
FASEB J. 2012;27(1):25-33 - PMID: 22972916 - DOI: 10.1096/fj.12-213744
Ogura Y, Ouchi N, Ohashi K, Shibata R, Kataoka Y, Kambara T, Kito T, Maruyama S, Yuasa D, Matsuo K, Enomoto T, Uemura Y, Miyabe M, Ishii M, Yamamoto T, Shimizu Y, Walsh K, Murohara T
Therapeutic impact of follistatin-like 1 on myocardial ischemic injury in preclinical models.
Circulation. 2012;126(14):1728-38 - PMID: 22929303 - PMCID: PMC3548325 - DOI: 10.1161/CIRCULATIONAHA.112.115089
Kambara T, Ohashi K, Shibata R, Ogura Y, Maruyama S, Enomoto T, Uemura Y, Shimizu Y, Yuasa D, Matsuo K, Miyabe M, Kataoka Y, Murohara T, Ouchi N
CTRP9 protein protects against myocardial injury following ischemia-reperfusion through AMP-activated protein kinase (AMPK)-dependent mechanism.
J Biol Chem. 2012;287(23):18965-73 - PMID: 22514273 - PMCID: PMC3365930 - DOI: 10.1074/jbc.M112.357939
Enomoto T, Ohashi K, Shibata R, Higuchi A, Maruyama S, Izumiya Y, Walsh K, Murohara T, Ouchi N
Adipolin/C1qdc2/CTRP12 protein functions as an adipokine that improves glucose metabolism.
J Biol Chem. 2011;286(40):34552-8 - PMID: 21849507 - PMCID: PMC3186379 - DOI: 10.1074/jbc.M111.277319
Hashimoto H, Enomoto T, Enomoto A, Kumano G, Nishida H
The transcription factor FoxB mediates temporal loss of cellular competence for notochord induction in ascidian embryos.
Development. 2011;138(12):2591-600 - PMID: 21610035 - DOI: 10.1242/dev.053082
Hashimoto H, Enomoto T, Enomoto A, Kumano G, Nishida H
The transcription factor FoxB mediates temporal loss of cellular competence for notochord induction in ascidian embryos.
Development. 2011;138(12):2591-600 - PMID: 21610035 - DOI: 10.1242/dev.053082