Center for Interdisciplinary Cardiovascular Sciences

van der Ven CFT, Tibbitt MW, Conde J, van Mil A, Hjortnaes J, Doevendans PA, Sluijter JPG, Aikawa E, Langer RS

Controlled delivery of gold nanoparticle-coupled miRNA therapeutics via an injectable self-healing hydrogel.

Nanoscale. 2021;13(48):20451-20461 - PMID: 34817483 - PMCID: PMC8675028 - DOI: 10.1039/d1nr04973a

Kraler S, Blaser MC, Aikawa E, Camici GG, Luscher TF

Calcific aortic valve disease: from molecular and cellular mechanisms to medical therapy.

Eur Heart J. 2021;43(7):683-697 - PMID: 34849696 - PMCID: PMC8843796 - DOI: 10.1093/eurheartj/ehab757

Human P, Bezuidenhout D, Aikawa E, Zilla P

Residual Bioprosthetic Valve Immunogenicity: Forgotten, Not Lost.

Front Cardiovasc Med. 2022;8:760635 - PMID: 35059444 - PMCID: PMC8764456 - DOI: 10.3389/fcvm.2021.760635

Tanaka T, Asano T, Okui T, Kuraoka S, Singh SA, Aikawa M, Aikawa E

Computational Screening Strategy for Drug Repurposing Identified Niclosamide as Inhibitor of Vascular Calcification.

Front Cardiovasc Med. 2022;8:826529 - PMID: 35127876 - PMCID: PMC8811128 - DOI: 10.3389/fcvm.2021.826529

Buffolo F, Monticone S, Camussi G, Aikawa E

Role of Extracellular Vesicles in the Pathogenesis of Vascular Damage.

Hypertension. 2022;79(5):863-873 - PMID: 35144490 - PMCID: PMC9010370 - DOI: 10.1161/HYPERTENSIONAHA.121.17957

Sawada H, Katsumata Y, Higashi H, Zhang C, Li Y, Morgan S, Lee LH, Singh SA, Chen JZ, Franklin MK, Moorleghen JJ, Howatt DA, Rateri DL, Shen YH, LeMaire SA, Aikawa M, Majesky MW, Lu HS, Daugherty A

Second Heart Field-derived Cells Contribute to Angiotensin II-mediated Ascending Aortopathies.

Circulation. 2022;145(13):987-1001 - PMID: 35143327 - PMCID: PMC9008740 - DOI: 10.1161/CIRCULATIONAHA.121.058173

Rogers MA, Atkins SK, Zheng KH, Singh SA, Chelvanambi S, Pham TH, Kuraoka S, Stroes ESG, Aikawa M, Aikawa E

Lipoprotein(a) Induces Vesicular Cardiovascular Calcification Revealed With Single-Extracellular Vesicle Analysis.

Front Cardiovasc Med. 2022;9:778919 - PMID: 35155626 - PMCID: PMC8831739 - DOI: 10.3389/fcvm.2022.778919

Passos LSA, Jha PK, Becker-Greene D, Blaser MC, Romero D, Lupieri A, Sukhova GK, Libby P, Singh SA, Dutra WO, Aikawa M, Levine RA, Nunes MCP, Aikawa E

Prothymosin Alpha: A Novel Contributor to Estradiol Receptor Alpha-Mediated CD8⁺ T-Cell Pathogenic Responses and Recognition of Type 1 Collagen in Rheumatic Heart Valve Disease.

Circulation. 2022;145(7):531-548 - PMID: 35157519 - PMCID: PMC8869797 - DOI: 10.1161/CIRCULATIONAHA.121.057301

Davidson SM, Boulanger CM, Aikawa E, Badimon L, Barile L, Binder CJ, Brisson A, Buzas E, Emanueli C, Jansen F, Katsur M, Lacroix R, Lim SK, Mackman N, Mayr M, Menasché P, Nieuwland R, Sahoo S, Takov K, Thum T, Vader P, Wauben MHM, Witwer K, Sluijter JPG

Methods for the identification and characterization of extracellular vesicles in cardiovascular studies - from exosomes to microvesicles.

Cardiovasc Res. 2022;119(1):45-63 - PMID: 35325061 - PMCID: PMC10233250 - DOI: 10.1093/cvr/cvac031

Alvandi Z, Nagata Y, Passos LSA, Hashemi Gheinani A, Guerrero JL, Wylie-Sears J, Romero DC, Morris BA, Sullivan SM, Yaghoubian KM, Alvandi A, Adam RM, Aikawa E, Levine RA, Bischoff J

Wnt Site Signaling Inhibitor Secreted Frizzled-Related Protein 3 Protects Mitral Valve Endothelium From Myocardial Infarction-Induced Endothelial-to-Mesenchymal Transition.

J Am Heart Assoc. 2022;11(7):e023695 - PMID: 35348006 - PMCID: PMC9075477 - DOI: 10.1161/JAHA.121.023695

Gomes NFA, Silva VR, Levine RA, Esteves WAM, de Castro ML, Passos LSA, Dal-Bianco JP, Pantaleão AN, da Silva JLP, Tan TC, Dutra WO, Aikawa E, Hung J, Nunes MCP

Progression of Mitral Regurgitation in Rheumatic Valve Disease: Role of Left Atrial Remodeling.

Front Cardiovasc Med. 2022;9:862382 - PMID: 35360029 - PMCID: PMC8962951 - DOI: 10.3389/fcvm.2022.862382

Aikawa E, Hutcheson JD

The Developmental Origin of Calcific Aortic Stenosis.

N Engl J Med. 2022;386(14):1372-1374 - PMID: 35388675 - DOI: 10.1056/NEJMcibr2200439

Garelnabi M, Cowdin M, Fang Y, Shrestha B, Ushio-Fukai M, Aikawa E, Graham G, Molema G, Yanagisawa H, Aikawa M

Embracing Diversity, Equity, and Inclusion in the Scientific Community-Viewpoints of the Diversity, Equity, and Inclusion Committee of the North American Vascular Biology Organization.

Front Cardiovasc Med. 2022;9:863256 - PMID: 35463765 - PMCID: PMC9021758 - DOI: 10.3389/fcvm.2022.863256

Dacano JL, Aikawa M, Singh SA

Promise of a Novel Bedside-to-Bench Paradigm: Can Percutaneous Coronary Intervention Proteomics Balloon Into Clinical Practice?

Arterioscler Thromb Vasc Biol. 2022;42(7):865-867 - PMID: 35616034 - DOI: 10.1161/ATVBAHA.122.317802

Sonawane AR, Aikawa E, Aikawa M

Connections for Matters of the Heart: Network Medicine in Cardiovascular Diseases.

Front Cardiovasc Med. 2022;9:873582 - PMID: 35665246 - PMCID: PMC9160390 - DOI: 10.3389/fcvm.2022.873582

Bartoli-Leonard F, Turner ME, Zimmer J, Chapurlat R, Pham T, Aikawa M, Pradhan AD, Szulc P, Aikawa E

Elevated lipoprotein(a) as a predictor for coronary events in older men.

J Lipid Res. 2022;63(8):100242 - PMID: 35724702 - PMCID: PMC9304778 - DOI: 10.1016/j.jlr.2022.100242

Paquin A, Marsit O, Deschênes V, Rouabhia D, Hadjadj S, Clisson M, Robitaille C, Aikawa E, Levine RA, Pibarot P, Clavel MA, Beaudoin J

Progression of aortic stenosis after an acute myocardial infarction.

Open Heart. 2022;9(1):ePub - PMID: 35728891 - PMCID: PMC9214429 - DOI: 10.1136/openhrt-2022-002046

Decano JL, Iwamoto Y, Goto S, Lee JY, Matamalas JT, Halu A, Blaser M, Lee LH, Pieper B, Chelvanambi S, Silva-Nicolau J, Bartoli-Leonard F, Higashi H, Shibata H, Vyas P, Wang J, Gostjeva E, Body SC, Singh SA, Aikawa M, Aikawa E

A disease-driver population within interstitial cells of human calcific aortic valves identified via single-cell and proteomic profiling.

Cell Rep. 2022;39(2):110685 - PMID: 35417712 - DOI: 10.1016/j.celrep.2022.110685

Asano T, Chelvanambi S, Decano JL, Whelan MC, Aikawa E, Aikawa M

In silico Drug Screening Approach Using L1000-Based Connectivity Map and Its Application to COVID-19.

Front Cardiovasc Med. 2022;9:842641 - PMID: 35402570 - PMCID: PMC8989014 - DOI: 10.3389/fcvm.2022.842641

Wang L, Xu GE, Pan L, Aikawa E, Aikawa M, Xiao J, Huang NF

Editorial: Frontiers in Cardiovascular Medicine: Rising Stars 2021.

Front Cardiovasc Med. 2022;9:928981 - PMID: 35757336 - PMCID: PMC9218798 - DOI: 10.3389/fcvm.2022.928981

Marsit O, Clavel MA, Paquin A, Deschênes V, Hadjadj S, Sénéchal-Dumais I, Couet J, Arsenault M, Handschumacher MD, Levine RA, Aikawa E, Pibarot P, Beaudoin J

Effects of Cyproheptadine on Mitral Valve Remodeling and Regurgitation After Myocardial Infarction.

J Am Coll Cardiol. 2022;80(5):500-510 - PMID: 35902173 - DOI: 10.1016/j.jacc.2022.05.025

Uchida S, Yu J, Goldman M, Asmis R, Yang X, Aikawa E, Bourantas C, Aikawa M, Tevaearai Stahel H

Editorial: Research reproducibility and preventing fraud.

Front Cardiovasc Med. 2022;9:979467 - PMID: 35979020 - PMCID: PMC9376614 - DOI: 10.3389/fcvm.2022.979467

Atkins SK, Sonawane AR, Brouwhuis R, Barrientos J, Ha A, Rogers M, Tanaka T, Okui T, Kuraoka S, Singh SA, Aikawa M, Aikawa E

Induced pluripotent stem cell-derived smooth muscle cells to study cardiovascular calcification.

Front Cardiovasc Med. 2022;9:925777 - PMID: 35958427 - PMCID: PMC9357895 - DOI: 10.3389/fcvm.2022.925777

Morgan S, Lee LH, Halu A, Nicolau JS, Higashi H, Ha AH, Wen JR, Daugherty A, Libby P, Cameron SJ, Mix D, Aikawa E, Owens AP, Singh SA, Aikawa M

Identifying novel mechanisms of abdominal aortic aneurysm via unbiased proteomics and systems biology.

Front Cardiovasc Med. 2022;9:889994 - PMID: 35990960 - PMCID: PMC9382335 - DOI: 10.3389/fcvm.2022.889994

Kuo A, Checa A, Niaudet C, Jung B, Fu Z, Wheelock CE, Singh SA, Aikawa M, Smith LEH, Proia RL, Hla T

Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasi.

Elife. 2022;11:ePub - PMID: 36197001 - PMCID: PMC9578713 - DOI: 10.7554/eLife.78861

Corti A, De Paolis A, Grossman P, Dinh PA, Aikawa E, Weinbaum S, Cardoso L

The effect of plaque morphology, material composition and microcalcifications on the risk of cap rupture: A structural analysis of vulnerable atherosclerotic plaques.

Front Cardiovasc Med. 2022;9:1019917 - PMID: 36277774 - PMCID: PMC9583261 - DOI: 10.3389/fcvm.2022.1019917

Krohn JB, Aikawa E, Aikawa M, Hutcheson JD, Sahoo S, Fish JE

Editorial: Extracellular vesicles in cardiovascular inflammation and calcification.

Front Cardiovasc Med. 2022;9:1077124 - PMID: 36426218 - PMCID: PMC9680153 - DOI: 10.3389/fcvm.2022.1077124

Sutton NR, Malhotra R, Hilaire CS, Aikawa E, Blumenthal RS, Gackenbach G, Goyal P, Johnson A, Nigwekar SU, Shanahan CM, Towler DA, Wolford BN, Chen Y

Molecular Mechanisms of Vascular Health: Insights From Vascular Aging and Calcification.

Arterioscler Thromb Vasc Biol. 2022;43(1):15-29 - PMID: 36412195 - PMCID: PMC9793888 - DOI: 10.1161/ATVBAHA.122.317332

Kum AST, De Moura DTH, Proença IM, Aikawa M, Sánchez-Luna SA, Ribeiro IB, Sasso JGRJ, Bestetti AM, Bernardo WM, Hourneaux de Moura EG

Gastroesophageal Reflux Waning Over Time in Endoscopic Versus Surgical Myotomy for the Treatment of Achalasia: A Systematic Review and Meta-Analysis.

Cureus. 2022;14(11):e31756 - PMID: 36569663 - PMCID: PMC9771598 - DOI: 10.7759/cureus.31756

Sud K, Narula N, Aikawa E, Arbustini E, Pibarot P, Merlini G, Rosenson RS, Seshan SV, Argulian E, Ahmadi A, Zhou F, Moreira AL, Côté N, Tsimikas S, Fuster V, Gandy S, Bonow RO, Gursky O, Narula J

The contribution of amyloid deposition in the aortic valve to calcification and aortic stenosis.

Nat Rev Cardiol. 2023;20(6):418-428 - PMID: 36624274 - PMCID: PMC10199673 - DOI: 10.1038/s41569-022-00818-2

Yagi H, Boeck M, Nian S, Neilsen K, Wang C, Lee J, Zeng Y, Grumbine M, Sweet IR, Kasai T, Negishi K, Singh SA, Aikawa M, Hellström A, Smith LEH, Fu Z

Mitochondrial control of hypoxia-induced pathological retinal angiogenesis.

Angiogenesis. 2024;27(4):691-699 - PMID: 39096357 - PMCID: PMC11564381 - DOI: 10.1007/s10456-024-09940-w

Kip P, Sluiter TJ, MacArthur MR, Tao M, Kruit N, Mitchell SJ, Jung J, Kooijman S, Gorham J, Seidman JG, Quax PHA, Decano JL, Aikawa M, Ozaki CK, Mitchell JR, de Vries MR

Preoperative methionine restriction induces perivascular adipose tissue browning and improves vein graft remodeling in male mice.

Nat Commun. 2024;15(1):9652 - PMID: 39511181 - PMCID: PMC11544300 - DOI: 10.1038/s41467-024-53844-8

Iwata A, Chelvanambi S, Asano T, Whelan M, Nakamura Y, Aikawa E, Sasaki Y, Aikawa M

Gene expression profiles of precursor cells identify compounds that reduce NRP1 surface expression in macrophages: Implication for drug repositioning for COVID-19.

Front Cardiovasc Med. 2024;11:1438396 - PMID: 39512370 - PMCID: PMC11541348 - DOI: 10.3389/fcvm.2024.1438396

Garelnabi M, Ntsekhe M, Doubell A, Aikawa M

Editorial: Global Excellence in Cardiovascular Medicine in Africa: challenges and opportunities.

Front Cardiovasc Med. 2024;11:1479281 - PMID: 39502195 - PMCID: PMC11534761 - DOI: 10.3389/fcvm.2024.1479281

Peng Q, Arulsamy K, Lu YW, Wu H, Zhu B, Singh B, Cui K, Wylie-Sears J, Li KS, Wong S, Cowan DB, Aikawa M, Wang DZ, Bischoff J, Chen K, Chen H

Novel Role of Endothelial CD45 in Regulating Endothelial-to-Mesenchymal Transition in Atherosclerosis.

bioRxiv. 2024;:ePub - PMID: 39282400 - PMCID: PMC11398423 - DOI: 10.1101/2024.09.03.610974

Yagi H, Boeck M, Petrishka-Lozenska M, Lundgren P, Kasai T, Cagnone G, Neilsen K, Wang C, Lee J, Tomita Y, Singh SA, Joyal JS, Aikawa M, Negishi K, Fu Z, Hellström A, Smith LEH

Timed topical dexamethasone eye drops improve mitochondrial function to prevent severe retinopathy of prematurity.

Angiogenesis. 2024;27(4):903-917 - PMID: 39287727 - PMCID: PMC11564262 - DOI: 10.1007/s10456-024-09948-2

Bhattacharjee S, Gao J, Lu YW, Eisa-Beygi S, Wu H, Li K, Birsner AE, Wong S, Song Y, Shyy JY, Cowan DB, Wei W, Aikawa M, Shi J, Chen H

Interplay Between FoxM1 and Dab2 Promotes Endothelial Cell Responses in Diabetic Wound Healing.

bioRxiv. 2024;:ePub - PMID: 39253510 - PMCID: PMC11383039 - DOI: 10.1101/2024.02.07.579019

Matamalas JT, Chelvanambi S, Decano JL, França RF, Halu A, Santinelli-Pestana DV, Aikawa E, Malhotra R, Aikawa M

Obesity and age are transmission risk factors for SARS-CoV-2 infection among exposed individuals.

PNAS Nexus. 2024;3(8):pgae294 - PMID: 39192848 - PMCID: PMC11348562 - DOI: 10.1093/pnasnexus/pgae294

Delwarde C, Aikawa M

Novel Mouse Model of Late-Stage Coronary Atherosclerosis With Features of Plaque Rupture and Stroke.

Circulation. 2024;150(9):706-709 - PMID: 39186532 - PMCID: PMC11540410 - DOI: 10.1161/CIRCULATIONAHA.124.070464

Katsuki S, Jha PK, Aikawa E, Aikawa M

The role of proprotein convertase subtilisin/kexin 9 (PCSK9) in macrophage activation: a focus on its LDL receptor-independent mechanisms.

Front Cardiovasc Med. 2024;11:1431398 - PMID: 39149582 - PMCID: PMC11324467 - DOI: 10.3389/fcvm.2024.1431398

Aikawa E, Allison MA, Iruela Arispe L, Bendeck MP, Chen Y, Gardiner EE, Golledge J, Suzuki-Inoue K, Marelli-Berg F, Powell JT, Ramasamy R, Sarpong DF, Sorci-Thomas MG, Daugherty A, Hegele RA, Schmidt AM

Honoring the Life and Legacy of Dr David A. Dichek.

Arterioscler Thromb Vasc Biol. 2024;44(7):1459-1461 - PMID: 38924433 - DOI: 10.1161/ATVBAHA.124.321293

Reyes-Soffer G, Matveyenko A, Lignos J, Matienzo N, Santos Baez LS, Hernandez-One A, Yung L, Nandakumar R, Singh SA, Aikawa M, George R, Ginsberg HN

Effects of Recombinant Human Lecithin Cholesterol Acyltransferase on Lipoprotein Metabolism in Humans.

Arterioscler Thromb Vasc Biol. 2024;44(6):1407-1418 - PMID: 38695168 - DOI: 10.1161/ATVBAHA.123.320387

Parthasarathy S, Saenjamsai P, Hao H, Ferkul A, Pfannenstiel JJ, Suder EL, Bejan DS, Chen Y, Schwarting N, Aikawa M, Muhlberger E, Orozco RC, Sullivan CS, Cohen MS, Davido DJ, Hume AJ, Fehr AR

PARP14 is pro- and anti-viral host factor that promotes IFN production and affects the replication of multiple viruses.

bioRxiv. 2024;:ePub - PMID: 38712082 - PMCID: PMC11071520 - DOI: 10.1101/2024.04.26.591186

Gordon LB, Basso S, Maestranzi J, Aikawa E, Clift CL, Cammardella AG, Danesi TH, Del Nido PJ, Edelman ER, Hamdy A, Hegde SM, Kleinman ME, Maschietto N, Mehra MR, Mukundan S, Musumeci F, Russo M, Rybicki FJ, Shah PB, Suarez WA, Tuminelli K, Zaleski K, Prakash A, Gerhard-Herman M

Intervention for critical aortic stenosis in Hutchinson-Gilford progeria syndrome.

Front Cardiovasc Med. 2024;11:1356010 - PMID: 38725831 - PMCID: PMC11079313 - DOI: 10.3389/fcvm.2024.1356010

Small AM, Yutzey KE, Binstadt BA, Voigts Key K, Bouatia-Naji N, Milan D, Aikawa E, Otto CM, St Hilaire C, American Heart Association Council on Genomic and Precision Medicine Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation and Council on Cardiovascular and Stroke Nursing

Unraveling the Mechanisms of Valvular Heart Disease to Identify Medical Therapy Targets: A Scientific Statement From the American Heart Association.

Circulation. 2024;150(6):e109-e128 - PMID: 38881493 - PMCID: PMC11542557 - DOI: 10.1161/CIR.0000000000001254

Raju S, Turner ME, Cao C, Abdul-Samad M, Punwasi N, Blaser MC, Cahalane RM, Botts SR, Prajapati K, Patel S, Wu R, Gustafson D, Galant NJ, Fiddes L, Chemaly M, Hedin U, Matic L, Seidman M, Subasri V, Singh SA, Aikawa E, Fish JE, Howe KL

Multi-omic Landscape of Extracellular Vesicles in Human Carotid Atherosclerotic Plaque Reveals Endothelial Communication Networks.

bioRxiv. 2024;:ePub - PMID: 38979218 - PMCID: PMC11230219 - DOI: 10.1101/2024.06.21.599781

Okui T, Kuraoka S, Iwashita M, Itagawa R, Kasai T, Aikawa M, Singh SA, Aikawa E

Carnitine O-octanoyltransferase (CROT) deficiency in mice leads to an increase of omega-3 fatty acids.

Front Mol Biosci. 2024;11:1374316 - PMID: 39076376 - PMCID: PMC11284101 - DOI: 10.3389/fmolb.2024.1374316

Yagi H, Boeck M, Petrishka-Lozenska M, Lundgren P, Kasai T, Cagnone G, gael.cagnone.1@gmail.com, Wang C, Lee J, Tomita Y, Singh SA, Joyal JS, Aikawa M, Negishi K, Fu Z, Hellström A, Smith LEH

Timed topical dexamethasone eye drops improve mitochondrial function to prevent severe retinopathy of prematurity.

Res Sq. 2024;:ePub - PMID: 38978601 - PMCID: PMC11230485 - DOI: 10.21203/rs.3.rs-4619093/v1

Kasai T, Nakamura Y, Aikawa M, Singh SA

In-Source Collision-Induced Dissociation (CID) Improves Higher-Energy Collisional Dissociation (HCD)-Dependent Fragmentation of ADP-Ribosyl Peptides.

Rapid Commun Mass Spectrom. 2025;39(4):e9961 - PMID: 39632390 - PMCID: PMC11617611 - DOI: 10.1002/rcm.9961

Chen ZB, Aikawa E, Alfaidi M, Ali K, Clift CL, Erbay E, Fredman G, Gomez D, Huang NF, Lu HS, Nguyen PK, Darc Oliveira S, Rodriguez-Miguelez P, SenthilKumar G, Zhang H, by the ATVB WLC

Institutional Support for the Career Advancement of Women Faculty in Science and Academic Medicine: Successes, Challenges, and Future Directions.

Arterioscler Thromb Vasc Biol. 2024;44(9):1916-1924 - PMID: 38957985 - PMCID: PMC11338710 - DOI: 10.1161/ATVBAHA.124.320910